Results 61 to 70 of about 218,183 (280)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Living well with Functional Neurological Disorder [PDF]

, 2023
Overview: This thesis explored concepts related to the experiences of living with Functional Neurological Disorder (FND). FND is known as a heterogeneous presentation of neurological symptoms that cannot be explained through known disease pathologies ...
Eccles, Fiona, Curvis, Will, Hughes, Jess   +2 more
core  

From Hysteria to Functional Neurological Symptom Disorder: Developments in Clinical Diagnosis and Neurobiology

Psikiyatride Güncel Yaklaşımlar
Changes in the nomenclature of functional neurological symptom disorders (FND) from the past to the present represent historical changes in understanding etiology. Today, there is still difficulty in excluding potential underlying neurological disorders.
Arda Bağcaz, Selvi Ceran
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Treatment outcomes in the inpatient management of severe functional neurological disorder: a retrospective cohort study. [PDF]

Functional neurological disorder (FND) is a heterogeneous condition; severe forms can be disabling. Multidisciplinary treatment and rehabilitation are recommended for severe FND, but there remains a lack of evidence for its efficacy and lack of ...
Bawa, Hetashi, Aslanyan, Daron, Coleman, Frances, Medford, N., Sigala, N., Jinadu, Helen, Saunders, C.   +6 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Narrative Therapy and Quality of Life in Functional Neurological Disorder

, 2023
Functional Neurological Disorder is a severely disabling and stigmatized condition in which motor or sensory neurological symptoms cannot be attributed to a known neurological condition and are considered to be psychological in nature.
Wilder, Amber
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A Practical Approach to Functional Neurological Disorder Diagnosis and Treatment

, 2023
Functional Neurological Disorder (FND), formerly known as conversion disorder, is a common yet often misunderstood diagnosis. FND is described as neurological symptoms without phenotypic features of a recognized neurological condition.
Sershon, Lisa M
core