Results 71 to 80 of about 218,183 (280)

Stressful life events and maltreatment in conversion (functional neurological) disorder: Systematic review and meta-analysis of case-control studies [PDF]

, 2018
Contains fulltext : 187770.pdf (Publisher’s version ) (Open Access)Background: Stressful life events and maltreatment have traditionally been considered crucial in the development of conversion (functional neurological) disorder, but ...
Nicholson, Timothy; id_orcid, Stone, J, Kanaan, Richard A, Ludwig, L., Roelofs, K., David, A.S., Ludwig, L, Joëlle A Pasman, Ludwig, Lea, Kanaan, Richard, Carson, Alan, Aybek, S, Nicholson, T., Tuck, Sharon, Karin Roelofs, Nicholson, T, David, AS, Pasman, Joëlle A, Selma Aybek, Aybek, S., Kanaan, R.A., Roelofs, Karin, Timothy Nicholson, Tuck, S, Kanaan, RA, Carson, A, Alan Carson, Lea Ludwig, Stone, Jon, Sharon Tuck, Richard A Kanaan, Tuck, Sharon; id_orcid, Stone, Jon; id_orcid, Pasman, Joëlle, Anthony S David, Nicholson, Timothy R, Nicholson, Timothy, Jon Stone, Aybek, Selma, Stone, J., Roelofs, K, Carson, A., Pasman, J.A., Tuck, S., Pasman, JA, David, Anthony S   +45 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The borderland of Multiple sclerosis and Functional Neurological Disorder: a call for clinical research and vigilance. [PDF]

, 2023
BACKGROUND Functional neurological disorders have attracted a lot of attention of the neurological medical community over the last decades as new development in neurosciences has reduced stigma around it by showing brain network dysfunctions.
Aybek, Selma, Chan, Andrew, Selma Aybek, Andrew Chan   +3 more
core   +1 more source

Screening for functional neurological disorders by questionnaire [PDF]

Journal of Psychosomatic Research, 2019
Diagnostic screening for functional neurological disorders (FNDs) continues to pose a challenge. Simple symptom counts fail clearly to discriminate patients with FND but there is increasing recognition of 'positive' features which are useful diagnostically during face-to-face assessments.
Shipston-Sharman, O., Hoeritzauer, I., Edwards, M., Reuber, M., Carson, A., Stone, J.   +5 more
openaire   +3 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Outcome Measures for Functional Neurological Disorder: A Review of the Theoretical Complexities.

, 2020
The development and selection of optimal outcome measures is increasingly recognized as a key component of evidence-based medicine, particularly the need for the development of a standardized set of measures for use in clinical trials.
Carson, A, Edwards, MJ, Hallett, M, Perez, DL, Nicholson, C, Stone, J, Goldstein, LH, Nielsen, G, Nicholson, TR, and the FND-COM (Functional Neurological Disorders Core Outcome, FND-COM group collaborators are as follows, Pick, S, Mildon, B   +12 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Role of functional imaging in neurological disorders [PDF]

Journal of Magnetic Resonance Imaging, 2006
AbstractNeuroimaging in recent years has greatly contributed to our understanding of a wide range of aspects related to central neurological diseases. These include the classification and localization of disease, such as in headache; the understanding of pathology, such as in Parkinson's disease (PD); the mechanisms of reorganization, such as in stroke
Weiller, Cornelius, May, Arne, Sach, Miriam, Buhmann, Carsten, Rijntjes, Michel   +4 more
openaire   +3 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source