Results 61 to 70 of about 4,839,288 (277)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Marmoset Brain Mapping V3: Population multi-modal standard volumetric and surface-based templates

NeuroImage, 2021
The standard anatomical brain template provides a common space and coordinate system for visualizing and analyzing neuroimaging data from large cohorts of subjects.
Cirong Liu, Cecil Chern-Chyi Yen, Diego Szczupak, Xiaoguang Tian, Daniel Glen, Afonso C. Silva   +5 more
doaj   +1 more source

[Overview of care management principles in functional neurological disorders]. [PDF]

, 2023
After more than twenty years of academic research on functional neurological disorders (FND) throughout the world, a standardized care management strategy has emerged to allow a more adapted care offer to patients with FND, as close as possible to their ...
Mouchabac, Stéphane, Othman Mounir Alaoui, Alaoui, Othman Mounir, Hingray, Coraline, Carle-Toulemonde, Guilhem, Aybek, Selma, Guilhem Carle-Toulemonde, Coraline Hingray, Stéphane Mouchabac, Garcin, Béatrice, Selma Aybek, Béatrice Garcin   +11 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A method to image brain tissue frozen at autopsy

NeuroImage
Magnetic Resonance Imaging (MRI) can provide the location and signal characteristics of pathological regions within a postmortem tissue block, thereby improving the efficiency of histopathological studies.
Govind Nair, Roy Sun, Hellmut Merkle, Qing Xu, Kyra Hoskin, Kendyl Bree, Stephen Dodd, Alan P. Koretsky   +7 more
doaj   +1 more source

Management of Anterocapitis and Anterocollis: A Novel Ultrasound Guided Approach Combined with Electromyography for Botulinum Toxin Injection of Longus Colli and Longus Capitis

Toxins, 2020
Chemodenervation of cervical musculature using botulinum neurotoxin (BoNT) is established as the gold standard or treatment of choice for management of Cervical Dystonia (CD).
Michael Farrell, Barbara I. Karp, Panagiotis Kassavetis, William Berrigan, Simge Yonter, Debra Ehrlich, Katharine E. Alter   +6 more
doaj   +1 more source

Multi-centre classification of functional neurological disorders based on resting-state functional connectivity

NeuroImage: Clinical, 2022
Background: Patients suffering from functional neurological disorder (FND) experience disabling neurological symptoms not caused by an underlying classical neurological disease (such as stroke or multiple sclerosis).
Samantha Weber, Salome Heim, Jonas Richiardi, Dimitri Van De Ville, Tereza Serranová, Robert Jech, Ramesh S. Marapin, Marina A.J. Tijssen, Selma Aybek   +8 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Dynamic Interhemispheric Desynchronization in Marmosets and Humans With Disorders of the Corpus Callosum

Frontiers in Neural Circuits, 2020
The corpus callosum, the principal structural avenue for interhemispheric neuronal communication, controls the brain’s lateralization. Developmental malformations of the corpus callosum (CCD) can lead to learning and intellectual disabilities. Currently,
Diego Szczupak, Diego Szczupak, Cecil C. Yen, Cirong Liu, Cirong Liu, Cirong Liu, Xiaoguang Tian, Xiaoguang Tian, Roberto Lent, Roberto Lent, Fernanda Tovar-Moll, Fernanda Tovar-Moll, Afonso C. Silva, Afonso C. Silva, in collaboration with the IRC5 Consortium   +14 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source