Results 71 to 80 of about 4,839,288 (277)

Functional neurological disorders: effective teaching for health professionals

BMJ Neurology Open, 2020
Objectives To provide an outline for the delivery of an educational course or lecture about functional neurological disorders (FND) that is directed towards health professionals with varying clinical knowledge and to highlight the educational efficacy ...
Alexander Lehn, Dharsha Navaratnam, Megan Broughton, Vince Cheah, Alison Fenton, Karl Harm, Diana Owen, Paul Pun   +7 more
doaj   +1 more source

Emotion processing in functional neurological disorder [PDF]

, 2018
Objective: Alexithymia and hypomentalization, two traits associated with childhood emotional abuse/neglect, have not previously been studied in people with mixed-symptom functional neurological disorder (FND).
Coy, G.
core  

Measuring disability in neurological rehabilitation : psychometric evaluation of two outcome measures. [PDF]

Objectives: To evaluate comprehensively the psychometric properties of the Functional Independence Measure (FIM) and the Functional Independence Measure + Functional Assessment Measure (FIM+FAM), and to compare their performance in stroke and ...
Hobart, Jeremy Charles
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Screening for functional neurological disorders by questionnaire [PDF]

Journal of Psychosomatic Research, 2019
Diagnostic screening for functional neurological disorders (FNDs) continues to pose a challenge. Simple symptom counts fail clearly to discriminate patients with FND but there is increasing recognition of 'positive' features which are useful diagnostically during face-to-face assessments.
Shipston-Sharman, O., Hoeritzauer, I., Edwards, M., Reuber, M., Carson, A., Stone, J.   +5 more
openaire   +3 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Real-world experience of teriflunomide in relapsing multiple sclerosis: paramagnetic rim lesions may play a role

Frontiers in Immunology
ObjectivesThe aims of this study were to report the effectiveness and safety of teriflunomide in Chinese patients with relapsing–remitting multiple sclerosis (RRMS) and to explore the association of paramagnetic rim lesion (PRL) burden with patient ...
Hongmei Tan, Hongmei Tan, Xiang Li, Xiang Li, Yuxin Li, Yuxin Li, Yuxin Li, Fanru He, Fanru He, Jingzi ZhangBao, Jingzi ZhangBao, Lei Zhou, Lei Zhou, Liqin Yang, Liqin Yang, Liqin Yang, Chongbo Zhao, Chongbo Zhao, Chuanzhen Lu, Chuanzhen Lu, Qiang Dong, Qiang Dong, Haiqing Li, Haiqing Li, Haiqing Li, Chao Quan, Chao Quan   +26 more
doaj   +1 more source

Role of functional imaging in neurological disorders [PDF]

Journal of Magnetic Resonance Imaging, 2006
AbstractNeuroimaging in recent years has greatly contributed to our understanding of a wide range of aspects related to central neurological diseases. These include the classification and localization of disease, such as in headache; the understanding of pathology, such as in Parkinson's disease (PD); the mechanisms of reorganization, such as in stroke
Weiller, Cornelius, May, Arne, Sach, Miriam, Buhmann, Carsten, Rijntjes, Michel   +4 more
openaire   +3 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source