Results 31 to 40 of about 55,585 (303)

Protocol of the Cognitive Health in Ageing Register: Investigational, Observational and Trial Studies in Dementia Research (CHARIOT): Prospective Readiness cOhort (PRO) SubStudy

BMJ Open, 2021
Introduction The Cognitive Health in Ageing Register: Investigational, Observational and Trial Studies in Dementia Research (CHARIOT): Prospective Readiness cOhort (PRO) SubStudy (CPSS), sponsored by Janssen Pharmaceutical Research & Development LLC,
Azeem Majeed, Miia Kivipelto, Craig W Ritchie, David Scott, Josip Car, Heather Ward, Karen Ritchie, Martin Cohn, Geraint Price, Susan Baker, Nzeera Ketter, Chinedu T. Udeh-Momoh, Tamlyn Watermeyer, Celeste A de Jager Loots, Natalia Reglinska-Matveyev, Michael Ropacki, Michael Fogle, Nandini Raghavan, Michael Arrighi, Robert Brashear, Jianing Di, Parthenia Giannakopoulou, Catherine Robb, Darina Bassil, Heather McLellan-Young, Jennifier Crispin, Kristina Lakey, Curry Lisa, Yellappa Chowdary Seemulamoodi, Dimitra Kafetsouli, Dinithi Perera, Robert Perneczky, Luc Bracoud, Ziad Saad, Gerald Novak, Lefkos Middleton   +35 more
doaj   +1 more source

Effect of supervised exercise on physical function and balance in patients with intermittent claudication [PDF]

, 2014
Background The aim of the study was to identify whether a standard supervised exercise programme (SEP) for patients with intermittent claudication improved specific measures of functional performance including balance. Methods A prospective observational
Chetter, I. C., Coughlin, P. A., Gohil, R. A., Khan, J. A., Mazari, F., Mockford, K. A., Vanicek, N.   +6 more
core   +1 more source

A Comparison of the Neuroprotective Efficacy of Newly Developed Oximes (K156, K203) and Currently Available Oximes (Obidoxime, HI-6) in Cyclosarin-poisoned Rats

Acta Medica, 2008
The neuroprotective effects of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with cyclosarin were studied.
Jiří Kassa, Jana Žďárová Karasová, Sandra Tesařová, Kamil Kuča, Kamil Musílek   +4 more
doaj   +1 more source

Optimal management of sarcopenia [PDF]

, 2010
Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function which occurs as a consequence of aging. With a growing older population, there has been great interest in developing approaches to counteract the effects of ...
Burton, Louise A., Sumukadas, Deepa
core   +6 more sources

Safety Pharmacology Study of ET-26 Hydrochloride, a Potential Drug for Intravenous General Anesthesia, in Rats and Beagle Dogs

Frontiers in Pharmacology, 2021
Background: ET-26 hydrochloride (ET-26HCl), a class 1 new drug, was developed to reserve the advantages of etomidate with a mild adrenocortical inhibition.Purpose: this study was to evaluate the potential adverse effects on the cardiovascular system of ...
YuJun Zhang, YuJun Zhang, YuJun Zhang, YingYing Jiang, YingYing Jiang, YingYing Jiang, Pan Chang, Pan Chang, Pan Chang, Yi Kang, Yi Kang, DeYing Gong, DeYing Gong, Jin Liu, Jin Liu, Jin Liu, WenSheng Zhang, WenSheng Zhang   +17 more
doaj   +1 more source

Reliability of the modified Rankin Scale: a systematic review [PDF]

, 2009
<p><b>Background and Purpose:</b> A perceived weakness of the modified Rankin Scale is potential for interobserver variability. We undertook a systematic review of modified Rankin Scale reliability studies.</p> <p><b ...
Dawson, J., Lees, K.R., Quinn, T.J., Walters, M.   +3 more
core   +1 more source

Assessment of cognitive scales to examine memory, executive function and language in individuals with Down syndrome: implications of a 6-month observational study

Frontiers in Behavioral Neuroscience, 2015
Down syndrome (DS) is the most commonly identifiable genetic form of intellectual disability. Individuals with DS have considerable deficits in intellectual functioning (i.e., low intellectual quotient, delayed learning and/or impaired language ...
Xavier Liogier D’Ardhuy, Jamie Ogline Edgin, Charles eBouis, Susana ede Sola, Susana ede Sola, Celia eGoeldner, Priya eKishnani, Jana eNöeldeke, Sydney eRice, Silvia eSacco, Lisa eSquassante, Gail eSpiridigliozzi, Jeannie eVisootsak, James eHeller, Omar eKhwaja   +14 more
doaj   +1 more source

Feasibility and performance of a device for automatic self-detection of symptomatic acute coronary artery occlusion in outpatients with coronary artery disease : a multicentre observational study [PDF]

, 2019
Background Time delay between onset of symptoms and seeking medical attention is a major determinant of mortality and morbidity in patients with acute coronary artery occlusion. Response time might be reduced by reliable self-detection.
Coeman, Mathieu, De Buyzere, Marc, De Pooter, Jan, Drieghe, Benny, Duytschaever, Mattias, El Haddad, Milad, Gevaert, Sofie, Gheeraert, Peter, Kayaert, Peter, Van Heuverswyn, Frederic, Vandekerckhove, Yves, Voet, Joeri   +11 more
core   +2 more sources

Anticholinergic Drugs – Functional Antidotes for the Treatment of Tabun Intoxication

Acta Medica, 2004
Summary: 1. To study the influence of antidotes on tabun-induced neurotoxicity, the rats were injected intramuscularly with organophosphate tabun (LD50).
Gabriela Krejčová, Jiří Kassa
doaj   +1 more source

Analysis of cognitive ability and adaptive behavior assessment tools used in an observational study of patients with mucopolysaccharidosis II

Orphanet Journal of Rare Diseases, 2021
Background Mucopolysaccharidosis II (MPS II) is a rare lysosomal storage disease characterized by cognitive impairment in most patients. This post hoc analysis evaluated changes in cognitive function, adaptive behavior and functional outcomes in patients
Karen S. Yee, Yanyu Wu, Magdalena Harrington, Susan E. Waisbren   +3 more
doaj   +1 more source