Results 141 to 150 of about 1,160,625 (318)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Role of Topical Mytomycin C Application in Improving Outcome of Functional Endoscopic Sinus Surgery [PDF]

, 2019
Mohammed A. El Dabaa, Atef A. El Maraghy, Mohammed A. Yones, Yahya M. Dawood, Mahmoud A. Megahed   +4 more
openalex   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Surgical and Functional outcome of Infective Knee Operated with Arthrotomy. [PDF]

J Orthop Case Rep
Shah M, Patel C, Gandhi M, Patel K.
europepmc   +1 more source

Subtotal and total glossectomies with or without total laryngectomy – Does laryngeal preservation impact oncological and functional outcomes?

Claudia Montenegro, Davide Mattavelli, Michele Tomasoni, Fatima-Ezzahra Nassih, Giulia Belponer, Claudia Modesti, Aurora Pinacoli, Vittorio Rampinelli, Davide Lancini, Alberto Grammatica, Cesare Piazza   +10 more
openalex   +2 more sources

A randomized multicenter trial to compare functional outcome and complications of surgical procedures for low rectal cancers

, 2011
Eugenijus Stratilatovas, E. Sangaila, Ž. Sinkevičius, Arvydas Burneckis, Eligijus Poškus, Kęstutis Strupas   +5 more
openalex   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Analysis of the Functional Outcome of Surgically Operated Floating Knee Injury. [PDF]

Cureus
J K BK, Rakshith A, Sagar BG, J T, Nafras A A M, Gowda PL.   +5 more
europepmc   +1 more source

Evaluating The Effects Of Lens Exchange And Correction Of Secondary Optical Aberrations To Improve Visual Functionality And Minimize Negative Perception Outcomes In Patients

Monika Izabela Popowska
openalex   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source