Results 121 to 130 of about 1,160,625 (318)
Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan +11 morewiley +1 more sourceEDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot +36 morewiley +1 more sourceSupplementary Material for: Peak Troponin I Levels Are Associated with Functional Outcome in Intracerebral Hemorrhage
, 2018 Stefan T. Gerner, Katrin Auerbeck, Maximilian I. Sprügel, Jochen A. Sembill, Dominik Madžar, Philipp Gölitz, Philip Hoelter, Joji B. Kuramatsu, Stefan Schwab, Hagen B. Huttner +9 moreopenalex +1 more sourceEngineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more sourcePartial versus radical nephrectomy in very elderly patients: a propensity score analysis of surgical, functional and oncologic outcomes (RESURGE project)
, 2019 Maria Carmen Mir, Nicola Pavan, Umberto Capitanio, Alessandro Antonelli, Ithaar Derweesh, Óscar Rodríguez-Faba, Estefanía Linares, Toshio Takagi, Koon Ho Rha, Christian Fiori, Tobias Maurer, Chao Zang, Alexandre Mottrie, Paolo Umari, Jean‐Alexandre Long, G. Fiard, Cosimo De Nunzio, Andrea Tubaro, Andrew Tracey, Matteo Ferro, Ottavio De Cobelli, Salvatore Micali, Luigi Bevilacqua, João Pimentel Torres, Luigi Schips, Roberto Castellucci, Ryan W. Dobbs, Giuseppe Quarto, Pierluigi Bove, Antonio Celia, Bernardino De Concilio, Carlo Trombetta, Tommaso Silvestri, Alessandro Larcher, Francesco Montorsi, Carlotta Palumbo, Maria Furlan, Ahmet Bindayı, Zachary Hamilton, Alberto Breda, Joan Palou, Alfredo Aguilera Bazán, Kazunari Tanabe, Ali Abdel Raheem, Thomas Amiel, Bo Yang, Estêvão Lima, Simone Crivellaro, Sisto Perdonà, Caterina Gregorio, Giulia Barbati, Francesco Porpiglia, Riccardo Autorino +52 moreopenalex +2 more sourcesSomatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen +5 morewiley +1 more source
