Results 101 to 110 of about 1,160,625 (318)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Neuropsychological deficits in patients with favorable outcomes after middle cerebral artery infarction treated with thrombectomy

open access: yesFrontiers in Neurology
IntroductionFunctional outcomes following stroke thrombectomy are commonly measured by the modified Rankin Scale (mRS). Due to hemisphere-specific representation of neuropsychological function, the mRS might underestimate persisting functional deficits ...
Hannah Hild   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Additional file 2: Table S1. of Prediction of mortality and functional outcome from status epilepticus and independent external validation of STESS and EMSE scores

open access: green, 2016
Bong Su Kang   +15 more
openalex   +1 more source

Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model [PDF]

open access: gold, 2017
Caryn Hampton   +13 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Functional Outcomes Following Surgical Fixation of Paediatric Lateral Condyle Fractures of the Elbow – A Systematic Review

open access: yesOrthopedic Research and Reviews, 2020
Nicholas Birkett,1 Karam Al-Tawil,1 Alexander Montgomery2 1Princess Alexandra Hospital, Harlow, Essex CM20 1QX, UK; 2Royal London Hospital, London E1 1FR, UKCorrespondence: Nicholas BirkettPrincess Alexandra Hospital, Hamstel Road, Harlow, Essex CM20 1QX,
Birkett N, Al-Tawil K, Montgomery A
doaj  

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