Results 81 to 90 of about 5,962,243 (238)

Radiological and Functional Assessment of Tibial Plateau Fractures Managed with Locking Compression Plates: A Prospective Study

Journal of Orthopaedic Case Reports
Introduction: Tibial plateau fractures are complex intra-articular injuries of the proximal tibia that can lead to significant functional impairment if not adequately managed.
Kanna Venkatakrishnaiah, Udit Agrawal, B K Vaibhav, Harsh Kirthi Rao, Gautam Chatterji   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Development and validation of a prognostic computed tomography scoring model for functional outcomes in patients with large hemispheric infarction following decompressive craniectomy

Frontiers in Neurology
BackgroundThere is no established prognostic scoring system developed for patients with large hemispheric infarction (LHI) following decompressive craniectomy (DC) based on imaging characteristics.
Yutong Zhao, Yuguang Tang, Zongyi Xie
doaj   +1 more source

Functional Outcomes following Surgical Management of Intradural Extramedullary Spinal Cord Tumors

Egyptian Spine Journal, 2015
Background Data: Intradural extramedullary tumors are mostly benign lesions that often present late due to their slow rate of growth. Recent advances in the field of neuro-imaging have greatly increased the ability to identify these tumors in early ...
Mohamed Elzoghby, Abdel Aal Abdel Baky
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Effect of age on the efficacy and safety of clopidogrel plus aspirin vs aspirin alone in acute mild-to-moderate stroke: a secondary analysis of the ATAMIS trial

Frontiers in Neurology
ObjectivesThe association between age and the effect of antiplatelet therapy on clinical outcomes in patients with ischemic stroke remains unclear. This study aimed to explore the effect of age on the efficacy and safety of dual versus mono antiplatelet ...
Hong-Ting Yan, Yu Cui, Zi-Ang Li, Ji-Ru Cai, Qi Wang, Xiao-Wen Hou, Hui-Sheng Chen   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Resistant Hypertension after Hypertensive Intracerebral Hemorrhage Is Associated with More Medical Interventions and Longer Hospital Stays without Affecting Outcome

Frontiers in Neurology, 2017
BackgroundHypertension (HTN) is the most common cause of spontaneous intracerebral hemorrhage (ICH). The aim of this study is to investigate the role of resistant HTN in patients with ICH.Methods and resultsWe conducted a retrospective study of all ...
Daojun Hong, Daojun Hong, Dana Stradling, Cyrus K. Dastur, Yama Akbari, Leonid Groysman, Lama Al-Khoury, Jefferson Chen, Steven L. Small, Wengui Yu   +9 more
doaj   +1 more source