Results 61 to 70 of about 1,160,625 (318)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The safety and use of perioperative dexamethasone in the perioperative management of primary sporadic supratentorial meningiomas

Frontiers in Oncology
ObjectiveDespite the lack of prospective evidence for the perioperative use of dexamethasone in meningioma surgery, its use is well established in the daily routine of several centers.
Felix Arlt, Felix Arlt, Alim Emre Basaran, Alim Emre Basaran, Markus Vogel, Markus Vogel, Martin Vychopen, Martin Vychopen, Clemens Seidel, Clemens Seidel, Alonso Barrantes-Freer, Alonso Barrantes-Freer, Erdem Güresir, Erdem Güresir, Johannes Wach, Johannes Wach   +15 more
doaj   +1 more source

Assessment of Clavicular Shortening in Displaced Midshaft Clavicular Fractures Treated by Nonoperative Method, Plating, and Elastic Nailing: Comparative Functional Analysis—A Case Series [PDF]

Journal of Orthopedics and Joint Surgery
Introduction: Clavicular shortening can occur after midshaft clavicular fractures, and its impact on functional outcomes has been a subject of interest in orthopedic research. Some studies have reported that clavicular shortening is associated with worse
Makesh Ram Sriraghavan, Poornima Kumararaja, Balakannan Jeyabalan   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Predictive value of hyponatremia for short-term mortality in supratentorial spontaneous intracerebral hemorrhage: a single center study

Frontiers in Neurology
BackgroundHyponatremia is a common electrolyte disturbance in patients with neurological disease; however, its predictive role for outcome in patients with supratentorial spontaneous intracerebral hemorrhage (sICH) is controversial.
Ao Qian, Longyi Zheng, Zeyuan He, Jing Zhou, Shuang Tang, Wenli Xing   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Nailing the Outcome: A Comparative Study of Proximal Femoral Nail Anti-Rotation-II and Trochanteric Fixation Nail in Unstable Intertrochanteric Femur Fractures

Journal of Orthopaedic Case Reports
Introduction: Intertrochanteric femur fractures are among the most common injuries in the elderly population and represent a major public health issue. Treatment aims to achieve stable fixation that allows early mobilization and minimizes complications ...
Ismail Pandor, Abhishek Sharma, Paresh Patil, Alim Shaikh, Anshuraj Jagdale, Jay Sankhala   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A retrospective cohort study on the seizure risks and outcomes of children with acquired brain injury

Frontiers in Neurology
BackgroundThe purpose of this study is to determine the prevalence, risk factors, and characteristics of seizures and epilepsy in children with acquired brain injury (ABI), and compare their outcomes with children with ABI but no seizures.MethodBasic ...
Vivien W. Y. Li, Yuliang Wang, Yuliang Wang, Winnie W. Y. Tso, Winnie W. Y. Tso, Winnie W. Y. Tso   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source