Results 51 to 60 of about 1,160,625 (318)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Role of Cognitive Reserve in Post-Stroke Rehabilitation Outcomes: A Systematic Review

Brain Sciences
Background/Objectives: Stroke remains a major cause of disability and death, with survivors facing significant physical, cognitive, and emotional challenges. Rehabilitation is crucial for recovery, but outcomes can vary widely. Cognitive reserve (CR) has
Debora Bertoni, Stefania Bruni, Donatella Saviola, Antonio De Tanti, Cosimo Costantino   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Functional Assessment of Congenital Radioulnar Synostosis in Children

Avicenna Journal of Medicine
Background Congenital radioulnar synostosis (CRUS) is a rare condition caused by segmentation failure in embryonic life. The forearm is usually fixed in pronation, affecting the upper limb and hand functions.
Isam Sami Moghamis, Hasan Abuhejleh, Yousef Abuodeh, Hazem Mohamad Nasef, Harris Manova Thanaraj, Ilse Du Preez, Mohamad Alaa Kawas   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Classical Orbital Floor Post-Traumatic Reconstruction vs. Customized Reconstruction with the Support of “In-House” 3D-Printed Models: A Retrospective Study with an Analysis of Volumetric Measurement

Diagnostics
Background: Orbital floor fractures (OFFs) represent an interesting chapter in maxillofacial surgery, and one of the main challenges in orbit reconstruction is shaping and cutting the precise contour of the implants due to its complex anatomy. Objective:
Elvis Kallaverja, Ida Barca, Francesco Ferragina, Maria Giulia Cristofaro   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The effect of argatroban on early neurological deterioration and outcomes in minor ischemic stroke: preliminary findings

Frontiers in Neurology
BackgroundMinor ischemic stroke (MIS) is associated with early neurological deterioration (END) and poor prognosis. Here, we investigated whether argatroban administration can mitigate MIS-associated END and improve functional outcomes by monitoring ...
Xuehong Jin, Xia Li, Hong Zhang, Xiaohan Yao, Yongquan Gu, Shaofang Pei, Lan Hu   +6 more
doaj   +1 more source

Scarcity in Plenty: Mirror Hand—A Case Report [PDF]

Journal of Orthopedics and Joint Surgery
Ulnar dimelia is an uncommon congenital anomaly of the hand. An absent thumb, multiple digits, and duplication of the forearm bones characterize it. Here, we have reported a case of a 2-year-old male child who presented to the hand surgery outpatient ...
Sriman Narayan Madan Mohan, Subashini Rajendiran, Srinivasan Rajappa   +2 more
doaj   +1 more source