Results 41 to 50 of about 1,160,625 (318)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Subtalar Arthroereisis as a Reliable Option for Flexible Flatfoot in Children – A Case Series [PDF]

Malaysian Orthopaedic Journal
Introduction: Conservative treatment in flexible flat foot (FFF) is preferred in most cases; only in symptomatic and conservative-refractory cases is surgical treatment proposed.
Miraj F, Karda IWAM, Noor EA
doaj   +1 more source

Functional outcomes of pancreaticoduodenoctomy

Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery, 2023
At present, pancreaticoduodenoctomy causes the high incidence of complications. However, it is associated with an acceptable level of postoperative mortality. With this regard and taking into consideration a significant increase in survival in pancreatic cancer, it is highly relevant to study the negative functional outcomes of surgery and develop ...
A. G. Kotelnikov, Y. I. Patyutko, D. V. Podluzhnyi, M. S. Saakyan, N. E. Kushlinski, N. V/ Lubimova, Y. S. Timofeev, R. G. Shakhbazyan, A. N. Polyakov, N. E. Kudashki, P. A. Tikhonov, I. S. Stilidi   +11 more
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

FUNCTIONAL OUTCOME OF TOTAL HIP

Journal of University Medical & Dental College, 2015
: Osteoarthritis is a chronic, progressive articular disorder characterized by pain. More than 10% of people older than 60 years of age are affected by osteoarthritis of the hip.
Osama Jafar, Aziz-ur-Rehman , M. Kaleem Shaukat   +2 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Functional outcomes of otosclerosis surgery

Brazilian Journal of Otorhinolaryngology
The objectives of this work were to evaluate the results of otosclerosis surgery and to study the predictors of its functional success.Our study was retrospective on 322 patients, equivalent to 418 ears operated in the otolaryngology and head and neck surgery department, from January 2000 to December 2020.Hearing success was noted in 89.5% of patients ...
Nadia Romdhane, Dorra Chiboub, Amal Nessib, Ameni Amri, Ines Hariga, Chiraz Chaouch Mbarek   +5 more
openaire   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Short-term functional outcome in children with arthrogryposis multiplex congenita after multiple surgeries at an early age

Journal of Multidisciplinary Healthcare, 2012
Moutasem M Obeidat,1 Ziad Audat,1 Wadah Khriesat21Department of Orthopedic Surgery, 2Department of Pediatrics, Jordan University of Science and Technology – King Abdullah University Hospital, Irbid, JordanPurpose: The purpose of this study is ...
Obeidat MM, Audat Z, Khriesat W
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source