Results 121 to 130 of about 2,750,599 (310)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Impact of Time from Diagnosis to Operating Room on Functional Outcomes in Patients with Traumatic Brain Injury: A Retrospective Study

Neurotrauma Reports
This study compares the functional outcomes of post-traumatic neurosurgical patients who underwent surgery within 4 h of diagnosis with those who underwent surgery >4 h after diagnosis.
Cheewin Khawprapa, Sasithorn Khawprapa
doaj   +1 more source

Fused kernel-spline smoothing for repeatedly measured outcomes in a generalized partially linear model with functional single index

, 2015
We propose a generalized partially linear functional single index risk score model for repeatedly measured outcomes where the index itself is a function of time.
Jiang, Fei, Ma, Yanyuan, Wang, Yuanjia
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Sex is not an independent predictor of 90-day outcomes after mechanical thrombectomy in Chinese patients with acute ischemic stroke: a prospective cohort study

Frontiers in Surgery
ObjectiveTo explore the impact of sex difference in the 90-day favourable outcome after mechanical thrombectomy(MT) with acute ischaemic stroke(AIS).MethodsWe consecutively enrolled AIS patients treated with MT from the First Affiliated Hospital of ...
Quan Liu, Sijia Liu, Jialin Yang, Qing He   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Extracorporeal shockwaves therapy for finger stenosing tenosynovitis: a systematic review and meta-analysis

Frontiers in Physiology
BackgroundStenosing tenosynovitis is a common chronic tendon disease that seriously affects daily life and working ability. However, its treatment is very challenging and requires more effective treatment methods.
Liyue Zhang, Yuan Luo, Yuan Luo, Li Chen, Xiong Zhang, Jinli Chen   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Early Screening of Sleep-Disordered Breathing Using a Smartphone-Based Portable System in Stroke Patients and Its Relevance for Rehabilitation: A Prospective Observational Study

Sensors
Sleep-disordered breathing (SDB) is common after stroke and may negatively influence recovery, yet it is frequently underdiagnosed. Portable respiratory monitoring devices could facilitate early SDB screening in these patients.
Sergiu Albu, Yolanda Castillo-Escario, Alicia Romero Marquez, Mónica López Andurell, Raimon Jané, Hatice Kumru   +5 more
doaj   +1 more source