Results 141 to 150 of about 365,137 (249)

Early diagnosis of Alzheimer's disease on ADNI data using novel longitudinal score based on functional principal component analysis. [PDF]

J Med Imaging (Bellingham), 2021
Shi H, Ma D, Nie Y, Faisal Beg M, Pei J, Cao J, Neuroimaging Initiative TAD.   +6 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Functional Principal Component Analysis of Aircraft Trajectories

, 2013
In Functional Data Analysis (FDA), the underlying structure of a raw observation is functional and data are assumed to be sample paths from a single stochastic process. Functional Principal Component Analysis (FPCA) generalizes the standard multivariate Principal Component Analysis (PCA) to the infinite-dimensional case by analyzing the covariance ...
openaire   +2 more sources

Lower-limb muscle activation patterns during the taekwondo roundhouse kick in elite and youth athletes: a functional principal component analysis. [PDF]

Front Bioeng Biotechnol
Sun J, Sun J, Sun G, Yin L, Shaharudin S.   +4 more
europepmc   +1 more source

Multivariate functional principal component analysis identifies waveform features of gait biomechanics related to early-to-moderate hip osteoarthritis. [PDF]

J Orthop Res, 2021
Roach KE, Pedoia V, Lee JJ, Popovic T, Link TM, Majumdar S, Souza RB.   +6 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Disjoint and Functional Principal Component Analysis for Infected Cases and Deaths Due to COVID-19 in South American Countries with Sensor-Related Data. [PDF]

Sensors (Basel), 2021
Martin-Barreiro C, Ramirez-Figueroa JA, Cabezas X, Leiva V, Galindo-Villardón MP.   +4 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Functional nonlinear principal component analysis

Computational Statistics & Data Analysis
Qingzhi Zhong, Xinyuan Song 0001
openaire   +2 more sources

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source