Results 151 to 160 of about 1,032,845 (272)
Dynamic prediction with time-dependent marker in survival analysis using supervised functional principal component analysis. [PDF]
Stat Med, 2022 Shi H, Jiang S, Cao J.
europepmc +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Supervised two-dimensional functional principal component analysis with time-to-event outcomes and mammogram imaging data. [PDF]
Biometrics, 2023 Jiang S, Cao J, Rosner B, Colditz GA.
europepmc +1 more source
DUZGUNLESTIRILMIS FONKSIYONEL ANA BILESENLER ANALIZI ILE IMKB VERILERININ INCELENMESI [PDF]
In most situations, modern technological developments give rise to the cases where samples are drawn from a population of real random functions. Functional Data Analysis (FDA) is an appropriate multivariate statistical approximation since the classical ...
Istem Koymen Keser, Kadir Ertas
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Testing differentially methylated regions through functional principal component analysis. [PDF]
J Appl Stat, 2022 Milad M, Olbricht GR.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Jointly modelling multiple transplant outcomes by a competing risk model via functional principal component analysis. [PDF]
J Appl Stat, 2023 Dong JJ, Shi H, Wang L, Zhang Y, Cao J.
europepmc +1 more source