Results 81 to 90 of about 681,398 (337)

Searching for Globally Optimal Functional Forms for Inter-Atomic Potentials Using Parallel Tempering and Genetic Programming [PDF]

, 2006
We develop a Genetic Programming-based methodology that enables discovery of novel functional forms for classical inter-atomic force-fields, used in molecular dynamics simulations. Unlike previous efforts in the field, that fit only the parameters to the
Peters, M. D., Slepoy, A., Thompson, A. P.   +2 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Functional Data Science for Secondary-School Students

Informatics in Education
CODAP is a widely-used programming environment for secondary school data science. Its direct-manipulation–based design offers many advantages to learners, especially younger students.
Paul Biberstein, Thomas Castleman, Luming Chen, Shriram Krishnamurthi   +3 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

A Brief Overview of the Pawns Programming Language

Software
This paper describes the Pawns programming language, currently under development, which uses several novel features to combine the functional and imperative programming paradigms.
Lee Naish
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Types of mathematical thinking implemented in the learn process of functional programming

Tecnura, 2018
Context: This article presents and analyzes the results of a research carried out in a classroom, in the context of the learning of functional programming at university level in Systems Engineering and Computing program, from the application of the types
Omar Iván Trejos Buriticá
doaj   +1 more source

Programming of refractive functions

Nature Communications
Abstract Snell’s law dictates the phenomenon of light refraction at the interface between two media. Here, we demonstrate arbitrary programming of light refraction through an engineered material where the direction of the output wave can be set independently for different directions of the input wave, covering arbitrarily selected ...
Md Sadman Sakib Rahman, Tianyi Gan, Mona Jarrahi, Aydogan Ozcan   +3 more
openaire   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

3D Dynamic Programming Approach to Functional Equations with Applications

Journal of Function Spaces, 2020
This article demonstrates the graphical existence of a single fixed point while imposing the contractive condition of Chatterjea type F-contraction on F-metric space (briefly as F-MS). We present two examples that verify the validity of the results given
Awais Asif, Sami Ullah Khan, Thabet Abdeljawad, Muahammad Arshad, Amjad Ali   +4 more
doaj   +1 more source