Results 101 to 110 of about 15,977,825 (398)
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Soybean Bioactive Peptides and Their Functional Properties
Nutrients, 2018 Soy consumption has been associated with many potential health benefits in reducing chronic diseases such as obesity, cardiovascular disease, insulin-resistance/type II diabetes, certain type of cancers, and immune disorders.
Cynthia Chatterjee, S. Gleddie, C. Xiao
semanticscholar +1 more source
A Classical Density-Functional Theory for Describing Water Interfaces
, 2012 We develop a classical density functional for water which combines the White Bear fundamental-measure theory (FMT) functional for the hard sphere fluid with attractive interactions based on the Statistical Associating Fluid Theory (SAFT-VR).
Alberts B. +6 more
core +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
ANCHOR: logically-centralized security for Software-Defined Networks [PDF]
, 2018 While the centralization of SDN brought advantages such as a faster pace of innovation, it also disrupted some of the natural defenses of traditional architectures against different threats.
Esteves-Verissimo, Paulo +3 more
core +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
The Effect of Nanofillers on the Functional Properties of Biopolymer-Based Films: A Review
Polymers, 2019 Waste from non-degradable plastics is becoming an increasingly serious problem. Therefore, more and more research focuses on the development of materials with biodegradable properties.
E. Jamróz, Piotr Kulawik, Pavel Kopel
semanticscholar +1 more source
Properties of the Hugoniot function [PDF]
Journal of Fluid Mechanics, 1958 Differentiation of the Hugoniot function $H (p,v) = E(p,v)-E(p_0,v_0)+\frac {1}{2}(p + p_0)(v_0 - v)$ and use of the first and second laws of thermodynamics leads to the relation dH = T dS+dA, where dA is the element of area in the (p, v) plane swept out (in a counter-clockwise direction) by the line segment (p0, v0) → (p, v) as the point (p, v) is ...
openaire +2 more sources
A Framework for Blockchain Interoperability and Runtime Selection
, 2019 The suitability of a particular blockchain for a given use case depends mainly on the blockchain's functional and non-functional properties. Such properties may vary over time, and thus, a selected blockchain may become unsuitable for a given use case ...
Borkowski, Michael +2 more
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