Results 71 to 80 of about 10,367,890 (306)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Transformation of wheat with high molecular weight subunit genes results in improved functional properties

, 1997
The high molecular weight (HMW) subunits of wheat glutenin are major determinants of the elastic properties of gluten that allow the use of wheat doughs to make bread, pasta, and a range of other foods. There are both quantitative and qualitative effects
Barcelo, P., Tatham, A. S., Gras, P., Paul A. Lazzeri, Bekes, F., Shewry, P. R., Fido, R., Francisco Barro, Lazzeri, P. A., Peter Gras, Frank Békés, Pilar Barceló, Arthur S. Tatham, Barro, F., Leonie Rooke, Roger Fido, Rooke, L., Peter R. Shewry, Shewry, Peter   +18 more
core   +1 more source

Comparative study of the structural and functional properties of protein isolates prepared from edible vegetable leaves

International Journal of Food Properties, 2020
Isoelectric precipitation was used to produce protein isolates (>90% protein contents) from three edible vegetable leaves. Amaranth (ALI), eggplant (ELI) and fluted pumpkin (FLI) leaf protein were isolated to study their conformational structures ...
Akinsola A. Famuwagun, Adeola M. Alashi, Saka O. Gbadamosi, Kehinde A. Taiwo, Durodoluwa J. Oyedele, Odunayo C. Adebooye, Rotimi E. Aluko   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A seed-extended algorithm for detecting protein complexes based on density and modularity with topological structure and GO annotations

BMC Genomics, 2019
Background The detection of protein complexes is of great significance for researching mechanisms underlying complex diseases and developing new drugs. Thus, various computational algorithms have been proposed for protein complex detection. However, most
Rongquan Wang, Caixia Wang, Liyan Sun, Guixia Liu   +3 more
doaj   +1 more source

Testing Properties of Generic Functions [PDF]

, 2007
A datatype-generic function is a family of functions indexed by (the structure of) a type. Examples include equality tests, maps and pretty printers. Property based testing tools like QuickCheck and Gast support the definition of properties and test-data generators, and they check if a monomorphic property is satisfied by the test cases.
Patrik Jansson, Johan Jeuring, Laurence Cabenda, Gerbo Engels, Jacob Kleerekoper, Sander Mak, Michiel Overeem, Kees Visser   +7 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Proximate Analysis and Techno-Functional Properties of Berberis aristata Root Powder: Implications for Food Industry Applications

Berberis aristata, commonly known as Indian barberry, has been traditionally used for its medicinal properties. Despite its recognized pharmacological benefits, its potential application in the food industry remains underexplored.
Awari, Ankita, ÖZ, Emel, Mohammad Rizwan Khan, Tomasevic, Igor, Khan, Mohammad Rizwan, Fatih Oz, Deepika Kaushik, Emel Oz, ÖZ, Fatih, Ankita Awari, Rizwan Wahab, Kaushik, Deepika, Igor Tomasevic, Ryszard Amarowicz, Wahab, Rizwan, Mukul Kumar, Charalampos Proestos, Amarowicz, Ryszard, Proestos, Charalampos, Kumar, MUKUL   +19 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source