Results 81 to 90 of about 1,610,238 (288)

Applying axiomatic design methodology in developing modified libertation products

Ingeniería e Investigación, 2004
Some conceptual elements regarding the axiomatic design method were applied to a specific case-study regarding developing modified liberation compressed product (CLM-UN), for use in the agricultural sector as pH regulating agent in solil.
Bibiana Margarita Vallejo Díaz, Carlos Julio Cortés Rodríguez, Armando Espinosa, Helber J. Barbosa B.   +3 more
doaj  

Getting the balance right between functional and non-functional requirements: the case of requirement specification in IT procurement

International Journal of Information Systems and Project Management, 2013
IT procurement represents a business process of high importance, including the ability to articulate requirements that the procurement deals with. Furthermore, specifying requirements is of importance for both procurer and potential supplier, as it ...
Björn Johansson, Markus Lahtinen, , ,
doaj   +1 more source

Tradeoff Analysis for Conflicting Software Non-Functional Requirements

IEEE Access, 2019
The need for particular software non-functional requirements (NFRs) leads a project team to use specific design strategies to fulfill these NFRs. However, some of the strategies may cause deficiencies in other software NFRs.
Xuan Zhang, Xu Wang
doaj   +1 more source

Modeling the decoherence of spacetime

, 1998
The question of whether unobserved short-wavelength modes of the gravitational field can induce decoherence in the long-wavelength modes (``the decoherence of spacetime'') is addressed using a simplified model of perturbative general relativity, related ...
A. Caldeira, A. Einstein, B. S. DeWitt, E. W. Kolb, G. Nordstrøm, G. Nordstrøm, G. Nordstrøm, G. Nordstrøm, H. A. Feldman, J. B. Hartle, J. B. Hartle, J. B. Hartle, J. J. Halliwell, John T. Whelan, M. Gell-Mann, R. Brandenberger, R. P. Feynman, T. Padmanabhan, T. Regge, V. V. Dodonov, W. Žurek, W. Žurek   +21 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Getting the balance right between functional and non-functional requirements: the case of requirement specification in IT procurement

International Journal of Information Systems and Project Management, 2022
IT procurement represents a business process of high importance, including the ability to articulate requirements that the procurement deals with. Furthermore, specifying requirements is of importance for both procurer and potential supplier, as it ...
Björn Johansson, Markus Lahtinen
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Design, fabrication and test of a 4750 Newton-meter-second double Gimbal control moment gyroscope [PDF]

The development of a prototype Control Moment Gyroscope (CMG) is discussed. Physical characteristics and the results of functional testing are presented to demonstrate the level of system performance obtained. Particular attention is given to how the man-
Blondin, Joseph, Cook, Lewis, Golley, Paul, Gurrisi, Charles, Kolvek, John, Krome, Henning   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source