Results 121 to 130 of about 2,383,427 (303)

Characteristics of cohort data management systems (CDMS): a scoping review

BMC Medical Research Methodology
Cohort studies are a core aspect of clinical research which helps to gather a large volume of data over time. As digital technologies evolve, managing these data has become increasingly complex. Therefore, the use of cohort data management systems (CDMS)
Arezoo Abasi, Haleh Ayatollahi, Seyed Abbas Motevalian   +2 more
doaj   +1 more source

iNKT subsets differ in their developmental and functional requirements on Foxo1. [PDF]

Proc Natl Acad Sci U S A, 2021
Zhang H, Zhang Y, Pan J, Wu Q, Huang Y, Bai S, Tian C, Zhu M, Lian Z, Li F, Tian Z, Bai L.   +11 more
europepmc   +1 more source

What Works Better? A Study of Classifying Requirements

, 2017
Classifying requirements into functional requirements (FR) and non-functional ones (NFR) is an important task in requirements engineering. However, automated classification of requirements written in natural language is not straightforward, due to the ...
Abad, Zahra Shakeri Hossein, Ghazi, Parisa, Glinz, Martin, Karras, Oliver, Ruhe, Guenther, Schneider, Kurt   +5 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

On systematically building a controlled natural language for functional requirements. [PDF]

Empir Softw Eng, 2021
Veizaga A, Alferez M, Torre D, Sabetzadeh M, Briand L.   +4 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing. [PDF]

G3 (Bethesda), 2021
Ostalé CM, Esteban N, López-Varea A, de Celis JF.   +3 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Advanced C and D techniques and application study [PDF]

A study was conducted to identify a broad base of payload control and display requirements for space missions. The subjects discussed are: (1) functional requirements and allocation analysis, (2) control and display generic device matrix, (3) control ...
Coscia, C., Kendall, K.
core   +1 more source