Results 171 to 180 of about 2,663,164 (310)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Polymeric α-Hairpinin Allergens Induce a Functional Response via a Single Antibody. [PDF]

Allergy
Leighton GO, Cosey TM, De Diavoukana ER, Lytle IR, Foo ACY, Pedersen LC, Gabel SA, Petrovich RM, Shi M, Aruva V, Creeks P, Wong JJW, Zhang J, Peebles RS, Croote D, Smith SA, Mueller GA.   +16 more
europepmc   +1 more source

Modelling Reference-Dependent and Labelling Effects in Consumers’ Functional Food Choices

This paper examines the reference-dependent and labelling effects when consumers make choices about functional foods, and explores how changes in reference points could alter individuals’ preferences.
Hobbs, Jill E., Zou, Ning Ning (Helen)
core  

Cortisol awakening response predicts intrinsic functional connectivity of the medial prefrontal cortex in the afternoon of the same day

, 2015
Cortisol awakening response (CAR) is the cortisol secretory activity in the first 30-60 min immediately after awakening in the morning. Alterations in CAR as a trait have been associated with changes in the brain structure and function.
Li, Wanqing, Liu, Chao, Zhang, Shen, Buchanan, Tony W., Zhang, Kan, Qin, Shaozheng, Wu, Jianhui, He, Yong, Yang, Zhi   +8 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Influence of light levels and predator characteristics on the functional response of the European harvestman (Opiliones: Phalangiidae). [PDF]

J Insect Sci
Stowe HE, Uiterwaal S.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

SEIRV epidemiological model for COVID 19 with Holling type II functional response. [PDF]

Sci Rep
Chakroborty S, Mostafa F.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A History of Methamphetamine Use Disorder in People with HIV Is Associated with Altered Functional Response to Risky Choice. [PDF]

Viruses
Happer JP, Tapert SF, Grant I, Bischoff-Grethe A, On Behalf Of The Translational Methamphetamine Aids Research Center Tmarc Group.   +4 more
europepmc   +1 more source