Results 101 to 110 of about 399,556 (306)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Вклад M. H. Кожиной e развитие лынгбыстыческой стилистики u становление речеведения
Stylistyka, 2021 Functional stylistics finds its origin in the works of Czech and Russian scholars of the 20-30s of the last century. In spite of great discoveries in the domain of methodology of this science, until the 1960s the functional-stylistic theory as an ...
ВЛАДИМИР A. САЛИМОВСКИЙ
doaj
Architectural design rewriting as an architecture description language [PDF]
, 2008 Architectural Design Rewriting (ADR) is a declarative rule-based approach for the design of dynamic software architectures. The key features that make ADR a suitable and expressive framework are the algebraic presentation of graph-based structures and ...
Bruni, Roberto +3 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Uncovering the functional aspect of translator style: corpus stylistic insights
Humanities & Social Sciences CommunicationsThis study employs a corpus stylistic approach to examine the functional aspect of translator style. It introduces and explores the concept of “translator’s functional style” through a case study of the Chinese-English translation of Lao She’s Er Ma.
Kan Wu
doaj +1 more source
Construction Stability Analysis of Curved Continuous Rigid Frame Bridges with High Piers
MATEC Web of Conferences, 2018 Taking the curved continuous rigid frame bridges (CRFBs) with high piers as research object, the construction stability of four different styles of main piers were analyzed by finite element (FE) method in three construction stages including the segment ...
Song Guohua, Li Minghui, Che Delu
doaj +1 more source
, 1987 Silicon compilation is a term used for many different purposes. In this paper we define silicon compilation as a mapping from some higher level description into layout.
Dutt, Nikil D. +2 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source