Results 101 to 110 of about 1,135,783 (296)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A review for design, mechanism, fabrication, and application of magnetically responsive microstructured functional surface

International Journal of Extreme Manufacturing
Magnetically responsive microstructured functional surface (MRMFS), capable of dynamically and reversibly switching the surface topography under magnetic actuation, provides a wireless, noninvasive, and instantaneous way to accurately control the ...
Jian Wang, Xingyi Song, Chaochao Wang, Yumei Zhou, Ri Chen, Yong Yang, Bin Liu, Yihao Zheng, Hui Li, Wei Zhou, Lelun Jiang   +10 more
doaj   +1 more source

Construction of functional surfaces for dental implants to enhance osseointegration. [PDF]

Front Bioeng Biotechnol, 2023
Wang Z, Wang J, Wu R, Wei J.
europepmc   +1 more source

Minimal Lagrangian surfaces in the tangent bundle of a Riemannian surface

, 2008
Given an oriented Riemannian surface $(\Sigma, g)$, its tangent bundle $T\Sigma$ enjoys a natural pseudo-K\"{a}hler structure, that is the combination of a complex structure $\J$, a pseudo-metric $\G$ with neutral signature and a symplectic structure ...
Anciaux, Henri, Guilfoyle, Brendan, Romon, Pascal   +2 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

CELL CYCLE REGULATION AND INDUCED NEUROGENESIS IN NEURAL STEM CELLS BY TOPOGRAPHICAL STIMULI

IBRO Neuroscience Reports, 2023
Miguel Esteban-Lucía, Jaime Hernández, Silvia García-López, Marta P. Pereira, Isabel Rodríguez   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Editorial: Functional surfaces and biomaterials. [PDF]

Front Bioeng Biotechnol, 2023
Liu Y, Krastev R, Wei J, Jiang M.
europepmc   +1 more source

Density functional theory study of Na at Al(111) and O at Ru(0001)

, 1996
The success of density functional theory for the description of the adsorption of atoms on surfaces is well established, and based on recent calculations using gradient corrections, it has been shown that it also describes well the dissociative ...
Stampfl, Catherine
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source