Results 121 to 130 of about 1,133,350 (295)

Bioinspired Design and Applications of Liquid Gating Gas Valve Membranes

Biomimetics
In nature, dynamic liquid interfaces play a vital role in regulating gas transport, as exemplified by the adaptive mechanisms of plant stomata and the liquid-lined alveoli, which enable efficient gas exchange through reversible opening and closing. These
Yiyao Li, Yang Liu, Rui Xu, Jing Liu, Xu Hou   +4 more
doaj   +1 more source

LIPSS-based functional surfaces produced by multi-beam nanostructuring with 2601 beams and real-time thermal processes measurement. [PDF]

Sci Rep, 2021
Hauschwitz P, Martan J, Bičišťová R, Beltrami C, Moskal D, Brodsky A, Kaplan N, Mužík J, Štepánková D, Brajer J, Rostohar D, Kopeček J, Prokešová L, Honner M, Lang V, Smrž M, Mocek T.   +16 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly. [PDF]

J Biol Chem, 2022
Liu SL, Narvaez-Ortiz HY, Miner M, Kiemel J, Oberhelman N, Watt A, Wagner AR, Luan Q, Helgeson LA, Nolen BJ.   +9 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Perspectives on Bioinspired Functional Surfaces for Heat Transfer Enhancement via Dropwise Condensation

Frontiers in Energy Research, 2022
Ze Xu, Raza Gulfam
doaj   +1 more source

Ceramics Surface Design by Laser Texturing: A Review on Structures and Functionalities

Advanced Materials Interfaces
Laser surface texturing (LST) employs high‐energy laser radiation to promote controlled material ablation, enabling the creation of surface features that can significantly enhance material performance.
Edna Silva, Augusto Lopes, Georgina Miranda   +2 more
doaj   +1 more source

How Do Cartilage Lubrication Mechanisms Fail in Osteoarthritis? A Comprehensive Review

Bioengineering
Cartilage degeneration is a characteristic of osteoarthritis (OA), which is often observed in aging populations. This degeneration is due to the breakdown of articular cartilage (AC) mechanical and tribological properties primarily attributed to ...
Manoj Rajankunte Mahadeshwara, Maisoon Al-Jawad, Richard M. Hall, Hemant Pandit, Reem El-Gendy, Michael Bryant   +5 more
doaj   +1 more source