Results 111 to 120 of about 11,051,876 (314)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The focal boundary value problem for strongly singular higher-order nonlinear functional-differential equations [PDF]
, 2015 The a priori boundedness principle is proved for the two-point right-focal boundary value problems for strongly singular higher-order nonlinear functional-differential equations.
Mukhigulashvili, Sulkhan +3 more
core +1 more source
Research Progress in Structure, Composition and Antiobesity Mechanism of Marine Polysaccharides [PDF]
Shipin KexueGlobally, obesity has become the fifth leading risk factor for death, and discoverying prebiotics with preventive and therapeutic effects on obesity is a hot topic in current research.
WANG Fuyi, YU Shuang, DONG Xinyu, CHEN Biyi,, LI Ying,, ZHAO Qiancheng, SANG Xue
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
New additions to Ericboehmia and Psiloglonium (Hysteriaceae, Hysteriales) based on morphology and multilocus phylogeny [PDF]
MycoKeysHysteriaceae is a taxonomically diverse family of ascomycetes, and continued taxonomic studies are improving our understanding of its species diversity and phylogenetic relationships. Two new species of Hysteriaceae, Ericboehmia guizhouensis sp.
Qing Yang +11 more
doaj +3 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Cross-Functional Processes in Customer Relationship Management [PDF]
Customer Relationship Management (CRM) is a strategic approach which involves creating a superior value for shareholders by developing relationships with certain categories of customers.
Cristian DUTU
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Rainbow plots, Bagplots and Boxplots for Functional Data [PDF]
We propose new tools for visualizing large numbers of functional data in the form of smooth curves or surfaces. The proposed tools include functional versions of the bagplot and boxplot, and make use of the first two robust principal component scores ...
Rob J. Hyndman, Han Lin Shang
core
A Functional Data Approach to Missing Value Imputation and Outlier Detection for Traffic Flow Data
, 2015 Missing values and outliers are frequently encountered in traffic monitoring data. We approach these problems by sampling the daily traffic flow rate trajectories from random functions and taking advantage of the data features using functional data ...
Chiou, Jeng-Min; Zhang, Yi-Chen; Chen, Wan-Hui; Chang, Chiung-Wen +2 more
core +1 more source