Results 91 to 100 of about 6,284,740 (249)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 2007 Lisa J. Green. "Syntactic Variation", Sociolinguistic Variation: Theories, Methods, and Applications. Ed. Robert Bayley and Ceil Lucas. Cambridge University Press, 2007.This chapter considers the syntax of dialects of English from a view that ...
Green, Lisa J
core +2 more sources
BMC Ecology and EvolutionLeaf traits were affected by soil factors and displayed varietal differences in forest. However, few examples have been reported on the Island ecosystems.
Sen Tong +6 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Frontiers in Marine Science, 2019 Environmental gradients can provide habitat-specific scenarios for community functional diversity (FD) that determine the composition of populations on both spatial and temporal scales.
Domênica Teixeira de Lima +9 more
doaj +1 more source
On Functional Central Limit Theorems for Dependent, Heterogeneous Tail Arrays with Applications to Tail Index and Tail Dependence Estimators [PDF]
We establish functional central limit theorems for a broad class of dependent, heterogeneous tail arrays encountered in the extreme value literature, including extremal exceedances, tail empirical processes and tail empirical quantile processes.
Jonathan Hill
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
PLoS Computational Biology, 2019 Differentiation between phenotypically neutral and disease-causing genetic variation remains an open and relevant problem. Among different types of variation, non-frameshifting insertions and deletions (indels) represent an understudied group with ...
Kymberleigh A Pagel +8 more
doaj +1 more source
The problem of the second variation of the discrete generalized Mayer form's functional
, 1998 The second variation of Mayer form's functional with distributed control is ...
Janušauskaitė, Nijolė +1 more
core +1 more source