Results 111 to 120 of about 75,347 (300)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Inconel 625/AISI 413 Stainless Steel Functionally Graded Material Produced by Direct Laser Deposition. [PDF]

Materials (Basel), 2021
Ferreira AA, Emadinia O, Cruz JM, Reis AR, Vieira MF.   +4 more
europepmc   +1 more source

Static and Dynamic Thermomechanical Buckling Loads of Functionally Graded Plates. [PDF]

, 2013
In the paper the buckling phenomenon for static and dynamic loading (pulse of finite duration) of FGM plates subjected to simultaneous action of one directional compression and thermal field is presented.
Kowal-Michalska, Katarzyna, Mania, Radosław J.   +1 more
core  

Study of heat transfer through functionally graded material fins using analytical and numerical investigations

Curved and Layered Structures
The present study used analytical and numerical methods to conduction works in functional graded material fin that is exposed to progressive boundary cooling and heating.
Hussein Adnan A., Jabbar Nasr A., Ahmed Sahib S., Aljibori H. S. S., Mohammed M. N., Alturaihi Muna Hameed, Al-Ansari Luay S., Abdullah Oday I.   +7 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Metal-polymer functionally graded materials for removing guided wave reflections at beam end boundaries [PDF]

, 2007
This paper investigates the potential of a metal-polymer functionally graded material (FGM) to remove beam end boundary wave reflections that produce complicated interference patterns in the response signals used for guided wave damage identification ...
Chavara, D. T., Liew, C. K., McCreery, M., Ruys, A. J., Veidt, M., Young, C.   +5 more
core  

Evaluation of mechanical properties of Ni/BaTiO3 functionally graded material

Mechanics & Industry
A Ni-BaTiO3 functionally graded material (FGM) was elaborated from 5 separate layers, ranging from 0 to 100 wt.% Ni content, by Spark Plasma Sintering (SPS) method.
Saidani Baraa, Zghal Jihed, Bruant Isabelle, Bregiroux Damien, Petit Johann, Cedelle Julie, Chevallier Gaël   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Investigation of stress intensity factor for internal cracks in FG cylinders under static and dynamic loading

Fracture and Structural Integrity, 2016
This paper investigates the variations of mode I stress intensity factor (KI) for inner penny-shaped and circumferential cracks in functionally graded solid and hollow thick walled cylinders, respectively with the changes of crack geometry, material ...
Mahmoud Shariati, Masoud Mahdizadeh Rokhi, Hassan Rayegan   +2 more
doaj