Results 41 to 50 of about 79,019 (297)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Free vibrations and static analysis of functionally graded sandwich plates with three-dimensional finite elements [PDF]

open access: yes, 2020
A three-dimensional modelling of free vibrations and static response of functionally graded material (FGM) sandwich plates is presented. Natural frequencies and associated mode shapes as well as displacements and stresses are determined by using the ...
Burlayenko, V. N., Sadowski, Tomasz
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Fabrication, Characterization and Modeling of Al2o3/Ni Functionally Graded Materials [PDF]

open access: yesEngineering and Technology Journal, 2014
Functionally graded materials (FGMs), with ceramic and metallic constituents, are frequently used for tremendous high temperature applications. In this paper, six sets of FGMs samples were designed and fabricated using powder technology technique.
Alaa Abdulhasan Atiyah
doaj   +1 more source

Three-dimensional free vibration analysis of thermally loaded fgm sandwich plates [PDF]

open access: yes, 2020
Using the finite element code ABAQUS and the user-defined material utilities UMAT and UMATHT, a solid brick graded finite element is developed for three-dimensional (3D) modeling of free vibrations of thermally loaded functionally gradient material (FGM)
Burlayenko, V. N.   +2 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Modeling and Evaluation of Vibrational Behavior in Functionally Graded Ceramic-Metal Composite Beams

open access: yesMağallaẗ Al-kūfaẗ Al-handasiyyaẗ
Functionally Graded Materials (FGMs) represent a notable advancement in materials research as they enable the smooth incorporation of distinct characteristics from various materials.
Ziadoon Mohammed Rahi, Hayder H. Khaleel
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

New Processing Route for the Production of Functionally Graded 7075 Al/SiCp Composites via a Combination of Semisolid Stirring and Sequential Squeeze Casting

open access: yesCrystals
Advanced processing techniques are required to produce functionally graded metal matrix composites due to the metallurgical conditions required during production.
Serhan Karaman Genc   +1 more
doaj   +1 more source

Corrosion Behavior of (Copper/Nickel) step-wise Functionally Graded Materials [PDF]

open access: yesArchives of Foundry Engineering
The present paper involves studying of the corrosion behaviour of five layers Cu/Ni Functionally Graded Materials (FGMs) in a 3.5 % NaCl solution to examine corrosion potentials (Ecorr.), corrosion current densities (icorr.) and Tafel slope. Three series
Dheya Abdulamer   +3 more
doaj   +1 more source

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