Results 41 to 50 of about 11,711 (265)

Investigation of the Static Bending Response of FGM Sandwich Plates [PDF]

Journal of Applied and Computational Mechanics
In the present work, a displacement-based high-order shear deformation theory is introduced for the static response of functionally graded plates. The present theory is variationally consistent and strongly similar to the classical plate theory in many ...
Lazreg Hadji, Vagelis Plevris, George Papazafeiropoulos   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Computational modeling of sigmoid functionally graded material (SFGM) plate

Materials Research Express, 2023
The first-order shear deformation theory (FSDT) was used to explore the natural frequency response of functionally graded piezoelectric plates subjected to static electrical and mechanical strain in this present study.
Jai Kumar Sharma, Sateesh Kumar, Nishant Kumar, S M Mozammil Hasnain, Shatrudhan Pandey, Ahmed Farouk Deifalla, Adham E Ragab   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Free Vibration Of Functionally Graded Carbon Nanotube Reinforced Composite Annular Sector Plate With General Boundary Supports

Curved and Layered Structures, 2018
In this paper, an efficient and unified approach for free vibration analysis of the moderately thick functionally graded carbon nanotube reinforced composite annular sector plate with general boundary supports is presented by using the Ritz method and ...
Pang Fuzhen, Li Haichao, Du Yuan, Shan Yanhe, Ji Fang   +4 more
doaj   +1 more source

Self-vibration of thin plate band with non-linear functionally graded material

Archives of Mechanics, 2012
The subject of this paper is the analysis of free vibration of a thin plate band made of nonlinear functionally graded material. The considered material has periodic properties in one direction and slow but non-linear functionally graded properties in ...
A. Wirowski
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Exact solution for bending analysis of functionally graded micro-plates based on strain gradient theory

Science and Engineering of Composite Materials, 2018
In the present article, static analysis of thin functionally graded micro-plates, based on Kirchhoff plate theory, is investigated. Utilizing the strain gradient theory and principle of minimum total potential energy, governing equations of rectangular ...
Mohammadi Meisam, Iranmanesh Afshin, Naseralavi Seyed Sadegh, Farahmand Hamed   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Computer Simulation of the Stress-Strain State of the Plate with Circular Hole and Functionally Graded Inclusion

Journal of Optimization, Differential Equations and Their Applications, 2021
Computer simulation of the behavior of a thin elastic rectangular plate with a circular hole and an annular inclusion made of functionally graded material has been carried out.
Eteri L. Hart, Bohdan I. Terokhin
doaj   +1 more source