Results 91 to 100 of about 5,311,244 (314)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Digital signature schemes based on Lucas functions
, 1995 In 1993 Lennon and Smith proposed to use Lucas functions instead of the exponentiation function as a one-way function in cryptographic mechanisms. Recently Smith and Skinner presented an ElGamal signature scheme based on Lucas functions.
Lucas Functions +3 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Chinese MedicineBackground Diabetic cardiomyopathy (DCM) is a cardiovascular complication, with cardiomyocyte senescence being a key pathological process. Cyclovirobuxine D (CVB-D), the active compound in Buxus sinica (Rehd. et Wils.) var. parvifolia M. Cheng. CVB-D has
Jiang-fei An +13 more
doaj +1 more source
Design and Synthesis of Flavonoidal Ethers and Their Anti-Cancer Activity In Vitro
Molecules, 2019 Flavonoids are well-characterized polyphenolic compounds with pharmacological and therapeutic activities. However, most flavonoids have not been developed into clinical drugs, due to poor bioavailability.
Lu Jin +7 more
doaj +1 more source
The Coefficients Of Functions With Positive Real Part And Some Special Classes Of Univalent Functions. [PDF]
, 2003 Several special classes of univalent functions f in the unit disk U are characterized by the quantity zf'(z)/ f (z) lies in a given region in the right-half plane.
M. Ali, Rosihan
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity
BMC Cancer, 2019 Background MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers.
Ning Wang +11 more
doaj +1 more source
Functionals on continuous functions [PDF]
Pacific Journal of Mathematics, 1974 Baxter, J. R., Chacon, R. V.
openaire +2 more sources