Results 71 to 80 of about 27,129 (305)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
On functions of bounded ω-variation, II [PDF]
Journal of the Australian Mathematical Society, 1965 Let ω(x) be a non-decreasing function defined in the interval [a, b]. We extend the definition to all x by taking ω(x) = ω(a) for x < a and ω(x) = ω(b) for x > b. R. L. Jeffery [2] has denoted by the class of functions F(x) defined as follows:
openaire +1 more source
A pointwise characterization of functions of bounded variation on metric spaces [PDF]
, 2013 Panu Lahti, Heli Tuominen
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Publicaciones en Ciencias y Tecnología, 2016 In this paper we introduce the notion of “function of second bounded variation” in the sense of Shiba, and we show that if a superposition operator applies the space of all such functions on itself and it is uniformly bounded, then its generating ...
José Giménez +3 more
doaj +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
On the differentiability of functions of bounded variation [PDF]
, 1936 Bohuš Jurek
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About the general chain rule for functions of bounded variation [PDF]
, 2023 Camillo Brena, Nicola Gigli
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source