Results 61 to 70 of about 27,805 (255)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

On convergence of Chlodovsky type Durrmeyer polynomials in variation seminorm

Journal of Numerical Analysis and Approximation Theory, 2018
This paper deals with the variation detracting property and rate of approximation of the Chlodovsky type Durrmeyer polynomials in the space of functions of bounded variation with respect to the variation seminorm.
Özlem Öksüzer Yilik, Harun Karsli, Fatma Tasdelen   +2 more
doaj   +2 more sources

Exploring Advanced Weighted Integral Inequalities via Extended Fractional Calculus Approaches

Fractal and Fractional
This paper investigates weighted Milne-type (M−t) inequalities within the context of Riemann–Liouville (R−L) fractional integrals. We establish multiple versions of these inequalities, applicable to different function categories, such as convex functions
Areej A. Almoneef, Abd-Allah Hyder, Hüseyin Budak, Mohamed A. Barakat   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Measure Functional Differential Equations in the Space of Functions of Bounded Variation

Abstract and Applied Analysis, 2013
We establish general conditions for the unique solvability of nonlinear measure functional differential equations in terms of properties of suitable linear majorants.
S. M. Afonso, A. Rontó
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Locally Defined Operators in the Space of Functions of Bounded Riesz-Variation

Journal of Mathematics, 2015
We study the locally defined operator on the spaces of bounded Riesz p-variation functions and we prove that those operators are the Nemytskii operator.
W. Aziz, J. A. Guerrero, K. Maldonado, N. Merentes   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

On the Convolution of Functions of Generalized Bounded Variations [PDF]

Georgian Mathematical Journal, 2006
Abstract Let 𝑓 and 𝑔 be 2π periodic functions. If 𝑓 ∈ 𝐿1[0, 2π] and 𝑔 is from ∧ 𝐵𝑉(𝑝)[0, 2π] or, Lip(α, 𝑝)[0, 2π] or, 𝑟 – 𝐵𝑉 [0, 2π], then 𝑓 convolution 𝑔 inherit the same property.
openaire   +2 more sources