Results 71 to 80 of about 401,077 (273)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Some Inequalities for Functions of Bounded Variation with Applications to Landau Type Results
, 2004 Some inequalities for functions of bounded variation that provide reverses for the inequality between the integral mean and the p-norm are established.
Dragomir, Sever Silvestru
core +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
On the Convolution of Functions of Generalized Bounded Variations [PDF]
Georgian Mathematical Journal, 2006 Abstract Let 𝑓 and 𝑔 be 2π periodic functions. If 𝑓 ∈ 𝐿1[0, 2π] and 𝑔 is from ∧ 𝐵𝑉(𝑝)[0, 2π] or, Lip(α, 𝑝)[0, 2π] or, 𝑟 – 𝐵𝑉 [0, 2π], then 𝑓 convolution 𝑔 inherit the same property.
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On convergence of Chlodovsky type Durrmeyer polynomials in variation seminorm
Journal of Numerical Analysis and Approximation Theory, 2018 This paper deals with the variation detracting property and rate of approximation of the Chlodovsky type Durrmeyer polynomials in the space of functions of bounded variation with respect to the variation seminorm.
Özlem Öksüzer Yilik +2 more
doaj +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Measure Functional Differential Equations in the Space of Functions of Bounded Variation
Abstract and Applied Analysis, 2013 We establish general conditions for the unique solvability of nonlinear measure functional differential equations in terms of properties of suitable linear majorants.
S. M. Afonso, A. Rontó
doaj +1 more source