Results 61 to 70 of about 500,560 (272)

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

open access: yesAdvanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka   +10 more
wiley   +1 more source

Patterns of Radiologic Service Utilization and Imaging Expenditure in Supercentenarians in Colombia

open access: yesAGING MEDICINE, EarlyView.
Analysis of Colombian administrative health data from 2014 to 2023 identified a distinct pattern of radiologic service utilization among supercentenarians (≥ 110 years). General radiology, ultrasound, and computed tomography were the most frequently used modalities, accounting for most imaging examinations.
Gabriela Puentes   +3 more
wiley   +1 more source

Informe anual 2019-2020 de la Fundación Propagas

open access: yes, 2020
Archivo digital original del informe disponible en: https://www.fundpropagas.com/.Los resultados de la gestión durante el 2019-2020 son presentados en esta memoria organizados según las distintas líneas estratégicas de la ...
Fundación Propagas
core  

Characterization and Analysis of PHEX Variants in Patients With Hypophosphatemia in Argentina

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Confirming the underlying molecular etiology of hereditary hypophosphatemia (HH) to provide recurrence risk counseling is highly important. Our aims were to describe the detected variants and their distribution across Argentina and to contrast them with published data.
Silvia Ávila   +3 more
wiley   +1 more source

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

open access: yesAnnals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca   +24 more
wiley   +1 more source

¿Reescribir la historia? El mito fundacional del Fuerte de los Ojuelos

open access: yesLetras Históricas
En las historias locales, los relatos fundacionales que perduran en el tiempo suelen construirse a partir de afirmaciones que no se sustentan en fuentes documentales sólidas, sino en argumentos verosímiles o plausibles dentro del imaginario colectivo. Se
José Antonio Medina Romo
doaj   +1 more source

Aclaración necesaria [PDF]

open access: yes, 2018
Con la finalidad de informar de mejor manera a la opinión pública, la Fundación Nacional para el Desarrollo (FUNDE) presenta con más detalle sus estimaciones a partir de la cual prevé que podría incrementarse el gasto del gobierno salvadoreño en concepto
Fundación Nacional para el Desarrollo, FUNDE
core  

MicroCT reinvestigation of the only articulated fossil anostomid fish reveals synonymy of Arhinolemur Ameghino, 1898 and Megaleporinus Ramirez et al., 2017

open access: yesThe Anatomical Record, EarlyView.
Abstract Arhinolemur scalabrinii† Ameghino, 1898 was originally described as a strepsirrhine primate (Mammalia) but has been recognized as an anostomid fish since 2012. It remains the only extinct anostomid species known from complete cranial material.
Karen M. Panzeri   +8 more
wiley   +1 more source

Foundation of Universidad de Oriente: Origins and Statutes

open access: yesSantiago, 2016
This paper expounds the historic origins of the foundation of the Universidsad de Oriente, on October 10th, 1947, and the essential contents of Law # 16 of 1949, which sanctioned the creation and functioning of the university, ratifying its organization ...
Vicente E. Escandell-Sosa
doaj  

Informe anual 2018 : 10 aniversario de la Fundación Propagas

open access: yes, 2018
Este informe anual se constituye en un valioso canal de comunicación de la Fundación Propagas con todos sus grupos de interés, describiendo los resultados y la evolución de los programas de la Fundación. Esta edición del informe celebra los primeros diez
Fundación Propagas
core  

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