Results 121 to 130 of about 8,493,253 (253)

Binary fractions and mass ratio distribution indices of 61 open clusters

open access: yesAstronomy & Astrophysics
Context. Open clusters (OCs) are crucial for studying stellar formation and evolution, while understanding binary stellar formation and star cluster dynamics is key to advancing the field of stellar astrophysics.
Lan Jie   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Franet National contribution to the Fundamental Rights Report 2025: Portugal

open access: yes
Disclaimer: This document was commissioned under contract as background material for a comparative analysis by the European Union Agency for Fundamental Rights (FRA) for the project ‘FRA Fundamental Rights Report 2025’.
Henriques, Marina   +2 more
core  

Classical and relative realizability [PDF]

open access: yes, 2016
We show that every abstract Krivine structure in the sense of Streicher can be obtained, up to equivalence of the resulting tripos, from a filtered opca (A,A') and a subobject of 1 in the relative realizability topos RT(A',A); the topos is always a ...
Zou, Tingxiang   +3 more
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Heegaard Floer correction terms, with a twist [PDF]

open access: yes, 2016
We use Heegaard Floer homology with twisted coefficients to define numerical invariants for arbitrary closed 3-manifolds equipped torsion spinc structures, generalising the correction terms (or d--invariants) defined by Ozsv\'ath and Szab\'o for integer ...
Fundamental mathematics   +3 more
core  

Positivity of the Green functions for higher order ordinary differential equations

open access: yesElectronic Journal of Differential Equations, 2008
We consider the equation $$ sum_{k=0}^n a_k(t)x^{(n-k)}(t)=0,quad tgeq 0, $$ where $a_0(t)equiv 1$, $a_k(t)$ ($k=1, dots, n$) are real bounded functions. Assuming that all the roots of the polynomial $z^n+a_1(t)z^{n-1}+ dots +a_n(t)$ ($tgeq 0$
Michael I. Gil'
doaj  

Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification

open access: yesHereditas
Introduction The bicoid (bcd) gene in Drosophila has served as a paradigm for a morphogen in textbooks for decades. Discovered in 1986 as a mutation affecting anterior development in the embryo, its expression pattern as a protein gradient later ...
Stefan Baumgartner
doaj   +1 more source

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