Results 141 to 150 of about 7,372,917 (304)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Franet National contribution to the Fundamental Rights Report 2025: Portugal

Disclaimer: This document was commissioned under contract as background material for a comparative analysis by the European Union Agency for Fundamental Rights (FRA) for the project ‘FRA Fundamental Rights Report 2025’.
Henriques, Marina, Barros, Diana, Nolasco, Carlos   +2 more
core  

The multi-planet system TOI-5624: four transiting sub-Neptunes with an outer companion revealed by transit-timing variations★

Astronomy & Astrophysics
Context. Following the 2022 alert of a TESS object of interest transiting TOI-5624 (a G7 V star ∼ 100 pc away), a CHEOPS campaign in 2023 detected four planetary signals at Pb ≈ 3.4, Pc ≈ 7.9, Pd ≈ 13.7, and Pe ≈ 21.5 days.
Bonfanti A., Gandolfi D., Leonardi P., Osborn H. P., Serrano L. M., Hébrard G., Billot N., Bekkelien A., Olofsson G., Broeg C., Nardiello D., Sousa S. G., Wilson T. G., Correia A. C. M., Pezzotti C., Brandeker A., Fossati L., Gillon M., Stalport M., Akinsanmi B., Alibert Y., Alonso R., Asquier J., Bárczy T., Barrado D., Barros S. C. C., Baumjohann W., Benz W., Borsato L., Castro-González A., Collier Cameron A., Csizmadia Sz., Cubillos P. E., Davies M. B., Deleuil M., Delfosse X., Deline A., Demangeon O. D. S., Demory B.-O., Derekas A., Destriez F., Edwards B., Ehrenreich D., Erikson A., Fortier A., Fridlund M., Gazeas K., Güdel M., Günther M. N., Hara N., Heidari N., Heitzmann A., Helling Ch., Isaak K. G., Keller T., Kiss L. L., Kitzmann D., Korth J., Lacedelli G., Lam K. W. F., Laskar J., Lecavelier des Etangs A., Leleu A., Lendl M., Magrin D., Maxted P. F. L., Mecina M., Merín B., Mordasini C., Nascimbeni V., Ottensamer R., Pagano I., Pallé E., Peter G., Piazza D., Piotto G., Pollacco D., Queloz D., Ragazzoni R., Rando N., Rauer H., Ribas I., Santos N. C., Scandariato G., Ségransan D., Simon A. E., Smith A. M. S., Sulis S., Szabó Gy. M., Udry S., Ulmer-Moll S., Van Grootel V., Venturini J., Verrecchia F., Villaver E., Walton N. A., Wolf S., Wolter D., Zingales T.   +98 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The GAPS programme at TNG

Astronomy & Astrophysics
The present-day architecture of planetary systems contains information about their formation and migration histories. The origin of hot Jupiters (HJs; P ≲ 10 d, Rp > 8 R⊕) has long been a matter of debate.
Mantovan G., Nascimbeni V., Desidera S., Malavolta L., Lissauer J. J., Leonardi P., Azevedo Silva T., Guerra C., Polychroni D., Borsato L., Baratella M., Biazzo K., Nardiello D., Collins K. A., Damasso M., De Leon J., Everett M. E., Gandolfi D., Giacalone S., Naponiello L., Piotto G., Scandariato G., Stassun K., Yee S. W., Affer L., Amadori F., Bignamini A., Colombo S., D’Arpa M., Dressing C. D., Fukui A., Ghedina A., Higuera J., Ikuta K., Kawauchi, Korth J., Lorenzi V., Mancini L., Mori M., Murgas F., Narita N., Palle E., Parviainen H., Ruggieri A., Savel A., Schwarz R. P., Shporer A., Srdoc G., Stockdale, Watanabe D., Zambelli R., Zingales T.   +51 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Stable pair invariants of surfaces and Seiberg-Witten invariants [PDF]

, 2016
Kool, M., Fundamental mathematics, Sub Fundamental Mathematics   +2 more
core   +3 more sources

Constraining the Galactic center dark cluster with ELT/MICADO observations

Astronomy & Astrophysics
The Galactic Center hosts the densest known stellar environment in the Milky Way, dominated by the massive black hole Sgr A* and the surrounding nuclear star cluster.
von Fellenberg Sebastiano D., Labaj Matúš, Ressler Sean M.   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source