Results 131 to 140 of about 670,593 (311)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Photometric Investigation of WY Leo: An Eclipsing Binary System with $\delta$ Scuti Component

Journal of Advanced Research in Natural and Applied Sciences
Eclipsing binary stars with $\delta$ components are exceptional systems for gaining a deeper understanding of stellar systems. WY Leo is one such system exhibiting $\delta$-type oscillations. However, it has not been extensively studied in the literature.
Filiz Kahraman Aliçavuş
doaj   +1 more source

International Initiative on X-ray Fundamental Parameters

International audienceAccurate critical data related to the interactions of X-rays with matter, called Fundamental Parameters (FP), are of paramount importance in many branches of physics and technology. These are the mass attenuation coefficients, X-ray
Lépy, Marie-Christine, Ménesguen, Y., Beckhoff, Burkhard   +2 more
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Developing a Multi-Element Sensor to Non-Destructively Monitor Several Fundamental Parameters Related to Concrete Durability. [PDF]

Sensors (Basel), 2020
Jin M, Ma Y, Zeng H, Liu J, Jiang L, Yang G, Gu Y.   +6 more
europepmc   +1 more source

Measurement of the sky photon background flux at the Auger Observatory

, 2005
The sky photon background flux has been measured at the southern Auger site in Malargüe, Argentina, using the observatory's fluorescence detectors (FD). The analysis is based on ADC variances of pixels not triggered by the First Level Trigger.
Salamida, F., Petrera, S., Privitera, P., Insolia, A., Verzi, V., Caruso, R.   +5 more
core  

Constraining fundamental stellar parameters using seismology:Application to α Centauri AB

, 2005
We apply the Levenberg-Marquardt minimization algorithm to seismic and classical observables of the αCen binary system in order to derive the fundamental parameters of αCenA+B, and to analyze the dependence of these parameters on the chosen observables,
A. Miglio, J. Montalbán, Montalban Iglesias, Josefa, Montalbán, J., Miglio, A., Montalban J., Miglio A.   +6 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source