Results 131 to 140 of about 7,372,917 (304)

Luminosity-Environment Relation in the Lowz Sample of the SDSS-III

Open Astronomy, 2016
In this work, we examine the environmental dependence of the u-, g-, r-, i- and z-band luminosities in the LOWZ sample of the Sloan Digital Sky Survey Data Release 10 (SDSS DR10).
Deng Xin-Fa, Qi Xiao-Ping, Wu Ping, Jiang Peng, Qian Xiao-Xia, Song Jun, Ding Ying-Ping   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Photometric Investigation of WY Leo: An Eclipsing Binary System with $\delta$ Scuti Component

Journal of Advanced Research in Natural and Applied Sciences
Eclipsing binary stars with $\delta$ components are exceptional systems for gaining a deeper understanding of stellar systems. WY Leo is one such system exhibiting $\delta$-type oscillations. However, it has not been extensively studied in the literature.
Filiz Kahraman Aliçavuş
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

European Union Agency for Fundamental Rights: Violence Against Women Survey, 2012

, 2015
copyright UK Data Service and data collection copyright owner.The European Union Agency for Fundamental Rights (FRA) has carried out the first survey on women's experiences of violence across the 28 Member States of the European Union (EU).
European Union Agency for Fundamental Rights (FRA)
core   +3 more sources

Developing a Multi-Element Sensor to Non-Destructively Monitor Several Fundamental Parameters Related to Concrete Durability. [PDF]

Sensors (Basel), 2020
Jin M, Ma Y, Zeng H, Liu J, Jiang L, Yang G, Gu Y.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The oldest Milky Way stars: New constraints on the age of the Universe and the Hubble constant

Astronomy & Astrophysics
Aims. In this work, we exploit the most robust, old, and cosmology-independent age estimates of individual stars from Gaia DR3 to place a lower bound on the age of the Universe, tU.
Tomasetti Elena, Chiappini Cristina, Nepal Samir, Moresco Michele, Lardo Carmela, Cimatti Andrea, Anders Friedrich, Queiroz Anna B. A., Limberg Guilherme   +8 more
doaj   +1 more source