Results 111 to 120 of about 670,593 (311)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Stellar Ages of TESS Stars, Adopting Spectroscopic Data from Gaia GSP-Spec
GalaxiesThe Gaia DR3 GSP-spec/TESS (GST) catalog combines asteroseismic data from NASA’s TESS mission with spectroscopic data from ESA’s Gaia mission, and contains about 116,000 Red Clump and Red Giant Branch stars, surpassing previous datasets in size and ...
Elisa Denis +6 more
doaj +1 more source
Sensitivity parameter and time variations of fundamental constants [PDF]
Journal of Physics G: Nuclear and Particle Physics, 2009 6 ...
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
RECENT VARIATIONS OF FUNDAMENTAL PARAMETERS AND THEIR IMPLICATIONS FOR GRAVITATION [PDF]
The Twelfth Marcel Grossmann Meeting, 2012 We compare the sensitivity of a recent bound on time variation of the fine structure constant from optical clocks with bounds on time varying fundamental constants from atomic clocks sensitive to the electron-to-proton mass ratio, from radioactive decay rates in meteorites, and from the Oklo natural reactor. Tests of the Weak Equivalence Principle also
openaire +2 more sources
Detection of Bridge Dynamic Parameters Using an Instrumented Vehicle
, 2012 5th World Conference on Structural Control and Monitoring, 12th-14th July, Tokyo, JapanHighway structures such as bridges are subject to continuous degradation primarily due to ageing and environmental factors.
McGetrick, P. +2 more
core
Photospheric properties and fundamental parameters of M dwarfs
, 2018 Context. M dwarfs are an important source of information when studying and probing the lower end of the Hertzsprung-Russell (HR) diagram, down to the hydrogen-burning limit.
Allard, F. +11 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source