Results 111 to 120 of about 583,814 (267)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

The multi-planet system TOI-5624: four transiting sub-Neptunes with an outer companion revealed by transit-timing variations★

Astronomy & Astrophysics
Context. Following the 2022 alert of a TESS object of interest transiting TOI-5624 (a G7 V star ∼ 100 pc away), a CHEOPS campaign in 2023 detected four planetary signals at Pb ≈ 3.4, Pc ≈ 7.9, Pd ≈ 13.7, and Pe ≈ 21.5 days.
Bonfanti A., Gandolfi D., Leonardi P., Osborn H. P., Serrano L. M., Hébrard G., Billot N., Bekkelien A., Olofsson G., Broeg C., Nardiello D., Sousa S. G., Wilson T. G., Correia A. C. M., Pezzotti C., Brandeker A., Fossati L., Gillon M., Stalport M., Akinsanmi B., Alibert Y., Alonso R., Asquier J., Bárczy T., Barrado D., Barros S. C. C., Baumjohann W., Benz W., Borsato L., Castro-González A., Collier Cameron A., Csizmadia Sz., Cubillos P. E., Davies M. B., Deleuil M., Delfosse X., Deline A., Demangeon O. D. S., Demory B.-O., Derekas A., Destriez F., Edwards B., Ehrenreich D., Erikson A., Fortier A., Fridlund M., Gazeas K., Güdel M., Günther M. N., Hara N., Heidari N., Heitzmann A., Helling Ch., Isaak K. G., Keller T., Kiss L. L., Kitzmann D., Korth J., Lacedelli G., Lam K. W. F., Laskar J., Lecavelier des Etangs A., Leleu A., Lendl M., Magrin D., Maxted P. F. L., Mecina M., Merín B., Mordasini C., Nascimbeni V., Ottensamer R., Pagano I., Pallé E., Peter G., Piazza D., Piotto G., Pollacco D., Queloz D., Ragazzoni R., Rando N., Rauer H., Ribas I., Santos N. C., Scandariato G., Ségransan D., Simon A. E., Smith A. M. S., Sulis S., Szabó Gy. M., Udry S., Ulmer-Moll S., Van Grootel V., Venturini J., Verrecchia F., Villaver E., Walton N. A., Wolf S., Wolter D., Zingales T.   +98 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Constraining the Galactic center dark cluster with ELT/MICADO observations

Astronomy & Astrophysics
The Galactic Center hosts the densest known stellar environment in the Milky Way, dominated by the massive black hole Sgr A* and the surrounding nuclear star cluster.
von Fellenberg Sebastiano D., Labaj Matúš, Ressler Sean M.   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Fundamental properties of two rapidly rotating stars: Rasalhague and Alkaid

Astronomy & Astrophysics
Context. The fundamental parameters of rapidly rotating stars are key quantities required to understand the impact of rotation on stellar evolution. A few nearby early-type stars offer the possibility to take precise measurements of these parameters ...
Lazzarotto Axel, Hui-Bon-Hoa Alain, Böhm Torsten, Gent Matt, Rieutord Michel   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source