Results 191 to 200 of about 206,533 (326)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

KIC 9656397: Long-period, Extremely Short-eclipse Detached Eclipsing Binary with Pulsation?

The Astronomical Journal
We conducted a detailed study of the 700 day light curve of KIC 9656397. The target is a long-period detached eclipsing binary, exhibiting short eclipses and out-of-eclipse variations, and is reported to be a member of the open star cluster NGC 6811.
Xiao-Hui Xu, Xu-Zhi Li, Qing-Feng Zhu, Gang Li, Jin-Sheng Qiu, Zi-Bin Meng, Pei-Ru Wu, Ke Hu, Yuan-Gui Yang, Jun-Han Zhao, Zhi-Yong Pu   +10 more
doaj   +1 more source

Fundamental stellar parameters of threeKeplerstars accurately constrained by lithium abundance and rotation [PDF]

, 2014
K. Liu, S. L. Bi, T. D. Li, Zhijia Tian, Zhishuai Ge   +4 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Toward Early-type Eclipsing Binaries as Extragalactic Milestones. IV. Physical Properties of Three Detached O/B-type Systems in the LMC

The Astrophysical Journal
We present a complete set of physical parameters for three early-type eclipsing binary systems in the Large Magellanic Cloud (LMC): OGLE LMC-ECL-17660, OGLE LMC-ECL-18794, and HV 2274, together with the orbital solutions.
Mónica Taormina, G. Pietrzyński, R.-P. Kudritzki, B. Pilecki, I. B. Thompson, J. Puls, M. Górski, B. Zgirski, D. Graczyk, M. A. Urbaneja, W. Gieren, W. Narloch, G. Hajdu   +12 more
doaj   +1 more source

The Galactic WN stars revisited. Impact of Gaia distances on fundamental stellar parameters [PDF]

, 2019
W.‐R. Hamann, G. Gräfener, A. Liermann, R. Hainich, A. A. C. Sander, T. Shenar, V. Ramachandran, H. Todt, L. M. Oskinova   +8 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Determination of the stars fundamental parameters using seismic scaling relations

, 2012
Seismology of stars that exhibit solar-like oscillations develops a growing interest with the wealth of observational results obtained with the CoRoT and Kepler space-borne missions. In this framework, relations between asteroseismic quantities and stellar parameters provide a unique opportunity to derive model-independent determinations of stellar ...
openaire   +2 more sources