Results 171 to 180 of about 207,560 (312)

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

On the Maximum Mass and Oblateness of Rotating Neutron Stars with Generic Equations of State

The Astrophysical Journal
A considerable effort has been dedicated recently to the construction of generic equations of state (EOSs) for matter in neutron stars. The advantage of these approaches is that they can provide model-independent information on the interior structure and
Carlo Musolino, Christian Ecker, Luciano Rezzolla   +2 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Photometric Analysis of 30 Contact Binaries in M31

The Astrophysical Journal
M31, as the largest galaxy in the Local Group, is of significant importance for the study of stellar formation and evolution. Based on the data of 5859 targets observed in M31 by Gu et al., we selected 30 contact binaries by visual inspection for further
Xiang Gao, Kai Li, Li-Heng Wang, Hai-bo Yuan, Hong-rui Gu, Ya-Ni Guo   +5 more
doaj   +1 more source

FUNDAMENTAL PARAMETERS OF SUPERGİANT STAR HD40589(A0Iab)

Odesa Astronomical Publications
У цій роботі були визначені фундаментальні параметри зорі-надгігінта HD 40589 (A0Iab), а саме ефективна температура (T eff ), прискорення сили тяжіння (log g), мікротурбулентна швидкість (ξt) і металічність [Fe/H]. Відстань до зорі 1734 пк. Висота над площиною Галактики становить 67,5 пк.
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

KIC 9656397: Long-period, Extremely Short-eclipse Detached Eclipsing Binary with Pulsation?

The Astronomical Journal
We conducted a detailed study of the 700 day light curve of KIC 9656397. The target is a long-period detached eclipsing binary, exhibiting short eclipses and out-of-eclipse variations, and is reported to be a member of the open star cluster NGC 6811.
Xiao-Hui Xu, Xu-Zhi Li, Qing-Feng Zhu, Gang Li, Jin-Sheng Qiu, Zi-Bin Meng, Pei-Ru Wu, Ke Hu, Yuan-Gui Yang, Jun-Han Zhao, Zhi-Yong Pu   +10 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Mass Transfer and Loss in an Extremely Low-mass-ratio Semidetached Binary with a Pulsating A-type Star

The Astrophysical Journal
AY Gem is a short-period Algol-type eclipsing binary with a period of 3.05 days that is neglected for spectroscopic and photometric investigations. The first radial-velocity curves have been obtained for AY Gem by using LAMOST medium- and low-resolution ...
Hui-Ting Zhang, Sheng-Bang Qian, Wen-Ping Liao   +2 more
doaj   +1 more source