Results 161 to 170 of about 166,438,504 (289)

First Photometric, Orbital Period, and Tidal Instability Investigations for Four Contact Binaries with Extremely Low Mass Ratios

The Astronomical Journal
Contact binaries with extremely low mass ratios, known as the most plausible progenitors of luminous red novae, are critical targets for refining theoretical models of binary mergers and investigating the lower mass ratio limit of contact binaries.
Yun-Xia Yu, Xue-Tong Liu, Zi-Bin Meng, Ke Hu, Zhen-Xin Lei, Fu-Yuan Xiang   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Tests of Disk-locking in T Tauri Stars of the Orion Nebula Cluster

The Astrophysical Journal
We look for specific correlations predicted by magnetospheric accretion models for young stars that assume disk-locking using stellar and accretion parameters derived from low-resolution HST-STIS spectra of 33 T Tauri stars in the Orion Nebula Cluster ...
Margaret A. Mueller, Christopher M. Johns-Krull, Keivan G. Stassun, Don M. Dixon   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Physical Parameters of 146 Contact Binaries Derived from Light and Radial Velocity Curves

The Astrophysical Journal Supplement Series
We present a comprehensive analysis of 146 contact binaries using medium-resolution Large Sky Area Multi-Object Fiber Spectroscopic Telescope spectra and photometric data from the All-Sky Automated Survey for Supernovae (ASAS-SN) and the Transiting ...
Kai Li, Xiang Gao, Si-Rui Wang, Li-Heng Wang   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Benchmark stars for mean stellar density and surface gravity estimates of solar-type stars

Adding an independent estimate of the mean stellar density, , as a constraint in the analysis of stars that host transiting exoplanets can significantly improve the precision of the planet radius estimate in cases where the light curve is too noisy to ...
Maxted, P F L
core   +1 more source

The First Photometric and Spectroscopic Study of Eight Large Amplitude Totally Eclipsing Contact Binaries

The Astronomical Journal
We present the first photometric and spectroscopic study of eight large amplitude totally eclipsing contact binary systems. Multiband ground-based light-curve analysis shows that all systems are W-subtype shallow contact binaries with mass ratios ranging
Yan-Rui Su, Kai Li, Li-Heng Wang, Meng Guo, Xiang Gao, Di-Fu Guo, Xing Gao, Shahidin Yaqup, Chunhai Bai, Ali Esamdin, Tuhong Zhong   +10 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source