Results 141 to 150 of about 207,560 (312)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

BSN. II. The First Light Curve Study of Eight Total Eclipsing Contact Binary Stars with Shallow Fillout Factors

The Astronomical Journal
This study provides the first comprehensive analysis of eight total-eclipse W Ursae Majoris-type contact binary systems. Ground-based photometric multiband observations were conducted at a Mexican observatory, and new times of minima were extracted.
Atila Poro, Kai Li, Raul Michel, Li-Heng Wang, Fahri Alicavus, Morgan Rhai Nájera, Priscila Santillán-Ortega, Francisco Javier Tamayo, Hector Aceves   +8 more
doaj   +1 more source

Chemical composition and fundamental parameters of roAp stars

, 1998
5 pages, 2 figures (the first being in fact a table), to appear in: Proc. of the 26th workshop of the European Working Group on CP stars, eds. P. North, A. Schnell and J. Ziznovsky, Contrib. Astr. Obs. Skalnate Pleso Vol.
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Accurate and Model-independent Radius Determination of Single FGK and M Dwarfs Using Gaia DR3 Data

The Astronomical Journal
Measuring fundamental stellar parameters is key to fully comprehending the evolution of stars. However, current theoretical models overpredict effective temperatures, and underpredict radii, compared to observations of K and M dwarfs (radius inflation ...
Rocio Kiman, Timothy D. Brandt, Jacqueline K. Faherty, Mark Popinchalk   +3 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

First Photometric, Orbital Period, and Tidal Instability Investigations for Four Contact Binaries with Extremely Low Mass Ratios

The Astronomical Journal
Contact binaries with extremely low mass ratios, known as the most plausible progenitors of luminous red novae, are critical targets for refining theoretical models of binary mergers and investigating the lower mass ratio limit of contact binaries.
Yun-Xia Yu, Xue-Tong Liu, Zi-Bin Meng, Ke Hu, Zhen-Xin Lei, Fu-Yuan Xiang   +5 more
doaj   +1 more source

Fundamental parameters of 8 Am stars: comparing observations with theory

, 2014
In this paper we present a detailed analysis of a sample of eight Am stars, four of them are in the {\it Kepler} field of view. We derive fundamental parameters for all observed stars, effective temperature, gravity, rotational and radial velocities, and chemical abundances by spectral synthesis method.
Catanzaro, G., Ripepi, V.
openaire   +2 more sources