Results 141 to 150 of about 166,438,504 (289)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Test of FeH Line Parameters Using DR19 APOGEE Spectra of Benchmark M Dwarfs

The Astrophysical Journal
Recent studies have suggested a mismatch of up to 0.20 dex between iron abundances derived from Fe I and FeH lines in the H -band spectra of M dwarfs and in this work we investigate the nature of this possible offset.
Anderson Silva-Andrade, Diogo Souto, Katia Cunha, Verne V. Smith, Carlos Allende Prieto, Ricardo P. Schiavon, Verónica Loaiza-Tacuri, Aida Behmard, Dmitry Bizyaev, Ilija Medan, Dan Qiu, Bárbara Rojas-Ayala   +11 more
doaj   +1 more source

The Fundamental Stellar Parameters of FGK Stars in the SEEDS Survey

, 2017
Large exoplanet surveys have successfully detected thousands of exoplanets to-date. Utilizing these detections and non-detections to constrain our understanding of the formation and evolution of planetary systems also requires a detailed understanding of the basic properties of their host stars.
Rich, Evan A., Wisniewski, John P., McElwain, Michael W., Hashimoto, Jun, Kudo, Tomoyuki, Kusakabe, Nobuhiko, Okamoto, Yoshiko K., Abe, Lyu, Akiyama, Eiji, Brandner, Wolfgang, Brandt, Timothy D., Cargile, Phillip, Carson, Joseph C., Currie, Thayne M, Egner, Sebastian, Feldt, Markus, Fukagawa, Misato, Goto, Miwa, Grady, Carol A., Guyon, Olivier, Hayano, Yutaka, Hayashi, Masahiko, Hayashi, Saeko S., Hebb, Leslie, Helminiak, Krzysztof G., Henning, Thomas, Hodapp, Klaus W., Ishii, Miki, Iye, Masanori, Janson, Markus, Kandori, Ryo, Knapp, Gillian R., Kuzuhara, Masayuki, Kwon, Jungmi, Matsuo, Taro, Mayama, Satoshi, Miyama, Shoken, Momose, Munetake, Morino, Jun-Ichi, Moro-Martin, Amaya, Nakagawa, Takao, Nishimura, Tetsuo, Oh, Daehyeon, Pyo, Tae-Soo, Schlieder, Joshua, Serabyn, Eugene, Sitko, Michael L., Suenaga, Takuya, Suto, Hiroshi, Suzuki, Ryuji, Takahashi, Yasuhiro H., Takami, Michihiro, Takato, Naruhisa, Terada, Hiroshi, Thalmann, Christian, Tomono, Daigo, Turner, Edwin L., Watanabe, Makoto, Yamada, Toru, Takami, Hideki, Usuda, Tomonori, Tamura, Motohide   +61 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Y Dwarf Companion to the White Dwarf WD 0806-66: Resolving the Discrepancy between Atmospheric and Evolutionary Models

The Astrophysical Journal
James Webb Space Telescope near- and mid-infrared spectroscopy has been published by M. Voyer et al. and B. W. P. Lew et al. for the Y dwarf, which is a distant companion to the white dwarf WD 0806-661.
S. K. Leggett, Pascal Tremblin
doaj   +1 more source

Fundamental Parameters for Central Stars of 103 Infrared Bow Shock Nebulae

The Astrophysical Journal
Abstract Stellar bow shock nebulae are arcuate shock fronts formed by the interaction of radiation-driven stellar winds and the relative motion of the ambient interstellar material. Stellar bow shock nebulae provide a promising means to measure wind-driven mass loss, independent of other established methods. In this work, we characterize
Nikhil Patten, Henry A. Kobulnicky, Matthew S. Povich, Angelica S. Whisnant, Sydney Andrews, Alexandra Boone, Srujan Dandu, Naomi Jones, S. Nick Justice, Dylan Hope, Alexander Larsen, Ryan McCrory, Julia Meredith, Maria Renee Meza, Alexandra C. Rosenthal, William Salazar, Alexander R. Sterling, Noshin Yesmin, Daniel A. Dale   +18 more
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

BSN. II. The First Light Curve Study of Eight Total Eclipsing Contact Binary Stars with Shallow Fillout Factors

The Astronomical Journal
This study provides the first comprehensive analysis of eight total-eclipse W Ursae Majoris-type contact binary systems. Ground-based photometric multiband observations were conducted at a Mexican observatory, and new times of minima were extracted.
Atila Poro, Kai Li, Raul Michel, Li-Heng Wang, Fahri Alicavus, Morgan Rhai Nájera, Priscila Santillán-Ortega, Francisco Javier Tamayo, Hector Aceves   +8 more
doaj   +1 more source