Results 131 to 140 of about 14,659 (294)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

FGK benchmark stars: Fundamental

Context. Large spectroscopic surveys devoted to the study of the Milky Way, including Gaia, use automated pipelines to determine the atmospheric parameters of millions of stars.
Heiter, Ulrike, N. Brouillet, Vitali, S., Brouillet, N.,, P. Jofré, Brouillet, N., Aguilera-Gomez, C., D. de Brito Silva, Soubiran, C., Vitali, S.,, Lagarde, N., Lagarde, N.,, Aguilera-Gomez, C.,, Heiter, Ulrike,, de Brito Silva, D.,, O. L. Creevey, Soubiran, C.,, U. Heiter, Heiter, U., L. Casamiquela, Creevey, O. L., de Brito Silva, D., N. Lagarde, S. Vitali, Creevey, O. L.,, Casamiquela, L., Worley, C.,, Jofre, P., C. Worley, C. Soubiran, Worley, C., Casamiquela, L.,, Jofre, P.,, C. Aguilera-Gómez   +33 more
core   +1 more source

Fundamental effective temperature measurements for eclipsing binary stars – V. The circumbinary planet system EBLM J0608–59 [PDF]

EBLM J0608$-$59/TOI-1338/BEBOP-1 is a 12$^{\rm th}$-magnitude, F9 V star in an eclipsing binary with a much fainter M dwarf companion on a wide, eccentric orbit (P = 14.6 d).
Duck, A.,, Sebastian, D; id_orcid, Martin, D. , V, Sebastian, D.,, Sebastian, D, Maxted, P. F. L., Triaud, A H M J, Triaud, A. H. M. J., Maxted, P. F. L.,, Duck, A, Miller, Nicola Jane,, Duck, A., Sebastian, D., Triaud, A. H. M. J.,, Triaud, A H M J; id_orcid, Maxted, P F L, Martin, D V, Miller, N J, Miller, Nicola Jane   +18 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Exploring NGC 7067: Comprehensive Analysis of Multiwavelength Photometric, Reddening, and Orbit Using Gaia DR3 and 2MASS

The Astrophysical Journal
This study used Bayesian analysis alongside various statistical methods to examine the young open cluster NGC 7067, utilizing Gaia DR3 and Two Micron All Sky Survey data.
Zihan Chen, Feng Wang, Huanbin Chi, Hui Deng, Ying Mei   +4 more
doaj   +1 more source

Fundamental Parameters for Central Stars of 103 Infrared Bow Shock Nebulae

The Astrophysical Journal
Abstract Stellar bow shock nebulae are arcuate shock fronts formed by the interaction of radiation-driven stellar winds and the relative motion of the ambient interstellar material. Stellar bow shock nebulae provide a promising means to measure wind-driven mass loss, independent of other established methods. In this work, we characterize
Nikhil Patten, Henry A. Kobulnicky, Matthew S. Povich, Angelica S. Whisnant, Sydney Andrews, Alexandra Boone, Srujan Dandu, Naomi Jones, S. Nick Justice, Dylan Hope, Alexander Larsen, Ryan McCrory, Julia Meredith, Maria Renee Meza, Alexandra C. Rosenthal, William Salazar, Alexander R. Sterling, Noshin Yesmin, Daniel A. Dale   +18 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The fundamental parameters of the starburst cluster Westerlund 1

, 2013
In spite of many published data about the starburst cluster Westerlund~1, fundamental parameters were not yet published -- at least not with the accuracy necessary for a template to massive star formation.
Neto, Augusto Damineli, Almeida, Leonardo Andrade de, Jablonski, Francisco Jose, Teodoro, Mairan Macedo   +3 more
core  

Fundamental parameters of subgiant stars in detached eclipsing binary systems [PDF]

, 2019
Detailed studies of stars in long-period, detached eclipsing binary systems remain one of the best ways to test stellar evolutionary models. With so many detections of planets outside of the solar system, research has turned to the characterisation of ...
Evans, Jessica Ann
core  

First Photometric, Orbital Period, and Tidal Instability Investigations for Four Contact Binaries with Extremely Low Mass Ratios

The Astronomical Journal
Contact binaries with extremely low mass ratios, known as the most plausible progenitors of luminous red novae, are critical targets for refining theoretical models of binary mergers and investigating the lower mass ratio limit of contact binaries.
Yun-Xia Yu, Xue-Tong Liu, Zi-Bin Meng, Ke Hu, Zhen-Xin Lei, Fu-Yuan Xiang   +5 more
doaj   +1 more source