Results 61 to 70 of about 14,824 (273)

Discovery of an Extremely r-process-enhanced Thin-disk Star with [Eu/H] = +0.78

The Astrophysical Journal Letters
Highly r -process-enhanced (RPE) stars are rare and usually metal poor ([Fe/H] < −1.0), and they mainly populate the Milky Way halo and dwarf galaxies. This study presents the discovery of a relatively bright ( V = 12.72), highly RPE ( r -II) star ([Eu ...
Xiao-Jin Xie, Jianrong Shi, Hong-Liang Yan, Tian-Yi Chen, Carlos Allende Prieto, Timothy C. Beers, Shuai Liu, Chun-Qian Li, Ming-Yi Ding, Yao-Jia Tang, Ruizhi Zhang, Renjing Xie   +11 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Time-series Spectroscopy and TESS Photometry of the Oscillating Eclipsing Algol System V389 Cassiopeiae

The Astronomical Journal
We present the results from a detailed analysis of our time-series spectroscopic observations and the Transiting Exoplanet Survey Satellite (TESS) photometric data of the eclipsing binary V389 Cas.
Pakakaew Rittipruk, Kyeongsoo Hong, Jae Woo Lee, Anirut Phriksee, Supachai Awiphan, Jae-Rim Koo, Jang-Ho Park   +6 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

TESS Asteroseismic Masses and Radii of Red Giants with (and without) Planets

The Astrophysical Journal
We present a study of asteroseismically derived surface gravities, masses, and radii of a sample of red giant stars both with and without confirmed planetary companions using TESS photometric light curves. These red giants were drawn from radial velocity
Myles Pope, Joleen K. Carlberg, Jeff Valenti, Doug Branton   +3 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Detection of the Temperature Dependence of the White Dwarf Mass–Radius Relation with Gravitational Redshifts

The Astrophysical Journal
Models predict that the well-studied mass–radius relation of white dwarf stars depends on the temperature of the star, with hotter white dwarfs having larger masses at a given radius than cooler stars.
Nicole R. Crumpler, Vedant Chandra, Nadia L. Zakamska, Gautham Adamane Pallathadka, Stefan Arseneau, Nicola Gentile Fusillo, J. J. Hermes, Carles Badenes, Priyanka Chakraborty, Boris T. Gänsicke, Stephen P. Schmidt   +10 more
doaj   +1 more source

Red Giants Search Method Based on Convolutional Neural Networks

The Astronomical Journal, 2023
Red giants play a crucial role in astronomical exploration. However, the current search for these stars heavily relies on spectrum analysis, making it a cumbersome process.
Hao Yuan, Meng Liu, Zechao Yang, Yude Bu, Zhenping Yi, Xiaoming Kong, Tianmin Wu, Ran Zhang   +7 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source