Results 71 to 80 of about 14,659 (294)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Simultaneous seismic modelling of multiple stars using correlated parameters
, 2021 The asteroseimsology of individual solar-like oscillators generally allows more precise inferences about many stellar model parameters than with only non-seismic constraints. Some of these parameters (e.g.
Ball, Warrick H.
core +1 more source
TESS Asteroseismic Masses and Radii of Red Giants with (and without) Planets
The Astrophysical JournalWe present a study of asteroseismically derived surface gravities, masses, and radii of a sample of red giant stars both with and without confirmed planetary companions using TESS photometric light curves. These red giants were drawn from radial velocity
Myles Pope +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Fundamental oscillation modes of self-interacting bosonic dark stars
, 2020 We perform a detailed analysis of the fundamental f-mode frequencies and damping times of nonrotating stellar-mass boson stars in general relativity by solving the nonradial perturbation equations.
Flores, C. Vasquez;Parisi, Alessandro;Chen, Chian-Shu;Lugones, German
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
LAMA: LAMOST Medium-Resolution Spectral Analysis Pipeline
The Astrophysical Journal Supplement SeriesThe Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) has obtained more than 23 million spectra, opening an unprecedented opportunity to study stellar physics, as well as the formation and evolution of our Milky Way.
Chun-qian Li +5 more
doaj +1 more source
The Astrophysical Journal, 2023 We report the discovery of 2M0056–08 as an equal-mass eclipsing binary (EB), comprising two red straggler stars (RSSs) with an orbital period of 33.9 days. Both stars have masses of ≈1.419 M _⊙ , identical to within 0.2%.
Keivan G. Stassun +9 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source