The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Homogeneous spectroscopic parameters for bright planet host stars from the northern hemisphere. The impact on stellar and planetary mass [PDF]
This work is supported by the European Research Council/European Community under the FP7 through Starting Grant agreement number 239953. N.C.S. was supported by FCT through the Investigador FCT contract reference IF/00169/2012 and POPH/FSE (EC) by FEDER ...
Mortier, Annelies +18 more
core +1 more source
Scaling K2. VIII. Short-period Sub-Neptune Occurrence Rates Peak Around Early-type M Dwarfs
We uniformly combined data from the NASA Kepler and K2 missions to compute planet occurrence rates across the entire FGK and M-dwarf stellar range. The K2 mission, driven by targets selected by guest observers, monitored nine times more M dwarfs than the
Kevin K. Hardegree-Ullman +8 more
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
The upcoming Chinese Space Station Telescope (CSST) slitless spectroscopic survey poses a challenge of flux calibration, which requires a large number of flux-standard stars.
Lin Yang +7 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Ten eclipsing binaries in the Small Magellanic Cloud: fundamental parameters and Cloud distance [PDF]
We present the first results of an observational programme to measure the fundamental parameters of over 100 eclipsing binaries in the Small Magellanic Cloud (SMC).
Hilditch, R.W. +2 more
core
Gravitoastronomy with neutron stars [PDF]
Recent advances in gravitational wave detectors mean that we can start to make astrophysically important statements about the physics of neutron stars based on observed upper limits to their gravitational luminosity.
Woan, G., Graham Woan
core +1 more source
Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
The Properties of V1016 Orionis, the Eclipsing Binary in the Trapezium System θ1 Orionis A
We have obtained high-dispersion spectroscopy, Strömgren y photometry, and Bessel BV measurements of the eclipsing binary V1016 Ori, which is part of the triple system θ ^1 Ori A that is one of the four bright Trapezium stars.
James R. Sowell +6 more
doaj +1 more source

