Results 91 to 100 of about 14,659 (294)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Detailed Investigation of a W UMa Contact Binary with an Ultralow Mass Ratio and a Third Body as a Potential Merger Candidate

The Astrophysical Journal
The lower limit of the mass ratio in contact binaries remains uncertain, with observations suggesting systems exist below theoretical predictions. The stability of such very-low-mass-ratio systems is still debated.
Atila Poro, Ehsan Paki, Fahri Alicavus, Raul Michel   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Low-mass Eclipsing Binaries KIC 4908495, KIC 6466939, and KIC 9474485: Isolated Pre-main-sequence Systems?

The Astrophysical Journal
We present a detailed analysis of three Kepler eclipsing binaries, KIC 4908495, KIC 6466939, and KIC 9474485. Our analysis reveals that these systems are composed of components possessing a lower mass than our Sun with slight subsolar metallicities ...
Orkun Özdarcan
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Challenges in inferring spectroscopic fundamental stellar parameters

, 2023
Fundamental stellar parameters are key for the understanding of many different fields in Astrophysics. There are several techniques available that can be used to characterize fundamental stellar parameters.
Sousa, Sérgio
core   +1 more source

Photometric and Spectroscopic Studies of Two Early-type Eclipsing Binaries

The Astrophysical Journal
Using high-precision photometric data from the Transiting Exoplanet Survey Satellite, medium-resolution spectroscopic data from the Large Sky Area Multi-Object Fiber Spectroscopy Telescope, and long-term eclipse timings, we provide orbital parameters for
Pengfei Ye, Kai Li, Fei Liu, Xiang Gao, Jing-Yi Wang   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Homogeneous spectroscopic parameters for bright planet host stars from the northern hemisphere. The impact on stellar and planetary mass

, 2015
This work is supported by the European Research Council/European Community under the FP7 through Starting Grant agreement number 239953. N.C.S. was supported by FCT through the Investigador FCT contract reference IF/00169/2012 and POPH/FSE (EC) by FEDER ...
Mortier, Annelies, A. Mortier, Sousa, S. G., Santos, N. C., V. Adibekyan, S. G. Sousa, Neves, V., Delgado Mena, E., B. Rojas-Ayala, E. Delgado Mena, Mortier, A.; id_orcid, Tsantaki, M., M. Tsantaki, N. C. Santos, Rojas-Ayala, B., G. Israelian, Israelian, G., Adibekyan, V., V. Neves   +18 more
core   +1 more source

OO Leo: An Active Contact Binary with Possible Solar-like Differential Rotation

The Astrophysical Journal
With Transiting Exoplanet Survey Satellite (TESS) high-precision photometry and Large Sky Area Multi-object Fiber Spectroscopic Telescope medium-resolution spectra, we present the first light and radial velocity curve analyses for the eclipsing binary OO
Zi-Bin Meng, Pei-Ru Wu, Yun-Xia Yu, Ke Hu, Fu-Yuan Xiang   +4 more
doaj   +1 more source