Results 101 to 110 of about 207,560 (312)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

LAMA: LAMOST Medium-Resolution Spectral Analysis Pipeline

The Astrophysical Journal Supplement Series
The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) has obtained more than 23 million spectra, opening an unprecedented opportunity to study stellar physics, as well as the formation and evolution of our Milky Way.
Chun-qian Li, Jian-rong Shi, Hong-liang Yan, Zhong-rui Bai, Jiang-tao Wang, Ming-yi Ding   +5 more
doaj   +1 more source

Accurate fundamental parameters of CoRoT asteroseismic targets: the solar-like stars HD 49933, HD 175726, HD 181420 and HD 181906

, 2009
The CoRoT satellite has provided high-quality light curves of several solar-like stars. Analysis of the light curves provides oscillation frequencies that make it possible to probe the interior of the stars.
Alcock, Andersen, Appourchaux, Bessell, Bruntt, Bruntt, Cenarro, Christensen-Dalsgaard, Clausen, Collet, Frankowski, Gillon, Grevesse, Gustafsson, H. Bruntt, Hauck, Heiter, Kjeldsen, Kovtyukh, Kovtyukh, Kupka, Makarov, Martell, Masana, Mayor, Michel, Mosser, Mosser, Nordström, North, North, Petrov, Pietrinferni, Ramírez, Rentzsch-Holm, Rogers, Solano, Stello, Valenti, van Leeuwen   +39 more
core   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Data-driven Stellar Intrinsic Colors and Dust Reddenings for Spectrophotometric Data: From the Blue-edge Method to a Machine Learning Approach

The Astrophysical Journal
Intrinsic colors (ICs) of stars are essential for studies on both stellar physics and dust reddening. In this work, we developed an XGBoost model to predict ICs with the atmospheric parameters T _eff , ${\rm{log}}\,g$ , and [M/H].
He Zhao, Shu Wang, Biwei Jiang, Jun Li, Dongwei Fan, Yi Ren, Xiaoxiao Ma   +6 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Scaling K2. VIII. Short-period Sub-Neptune Occurrence Rates Peak Around Early-type M Dwarfs

The Astronomical Journal
We uniformly combined data from the NASA Kepler and K2 missions to compute planet occurrence rates across the entire FGK and M-dwarf stellar range. The K2 mission, driven by targets selected by guest observers, monitored nine times more M dwarfs than the
Kevin K. Hardegree-Ullman, Galen J. Bergsten, Jessie L. Christiansen, Jon K. Zink, Sakhee Bhure, Kiersten M. Boley, Rachel B. Fernandes, Steven Giacalone, Preethi R. Karpoor   +8 more
doaj   +1 more source

The Penn State - Toru\'n Planet Search: target characteristics and recent results

, 2011
More than 450 stars hosting planets are known today but only approximately 30 planetary systems were discovered around stars beyond the Main Sequence.
Adamów, M., Gettel, S., Niedzielski, A., Nowak, G., Wolszczan, A., Zieliński, P.   +5 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Star-based Method for the Precise Flux Calibration of the Chinese Space Station Telescope Slitless Spectroscopic Survey

The Astrophysical Journal Supplement Series
The upcoming Chinese Space Station Telescope (CSST) slitless spectroscopic survey poses a challenge of flux calibration, which requires a large number of flux-standard stars.
Lin Yang, Haibo Yuan, Fuqing Duan, Ruoyi Zhang, Bowen Huang, Kai Xiao, Shuai Xu, Jinming Zhang   +7 more
doaj   +1 more source