Results 101 to 110 of about 14,659 (294)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Fundamental effective temperature measurements for eclipsing binary stars – VII. The solar twin in LL Aquarii

The eclipsing binary LL Aqr is a bright V=9.32, detached system consisting of two solar-type stars in an eccentric orbit (P = 20.2 d). The secondary component, LL Aqr B, was previously found to have physical and atmospheric parameters very similar to the
Maxted, Pierre, Graczyk, Dariusz, Miller, Nicola, Hahlin, Axel   +3 more
core   +1 more source

An Extremely Hot Pulsating Prewhite Dwarf from OGLE

The Astronomical Journal
We show that the blue 18.3 minutes variable object discovered in the Galactic disk by the OGLE-III survey and named OGLE-GD-WD-0001 is a pulsating prewhite dwarf of PG 1159 spectral type.
Paweł Pietrukowicz, Klaus Werner, Mateusz J. Mróz, Milena Ratajczak   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Ten eclipsing binaries in the Small Magellanic Cloud: fundamental parameters and Cloud distance

, 2003
We present the first results of an observational programme to measure the fundamental parameters of over 100 eclipsing binaries in the Small Magellanic Cloud (SMC).
Hilditch, R.W., Harries, T.J., Howarth, I.D.   +2 more
core  

The First Photometric Analysis of Two Low-mass-ratio Contact Binary Systems in TESS Survey

The Astronomical Journal
Low-mass-ratio ( q ) contact binary systems are progenitors of stellar mergers such as blue stragglers or fast-rotating FK Com stars. In this study, we present the first light curve analysis of two newly identified low mass-ratio contact binary systems ...
Qiyuan Cheng, Jianping Xiong, Xu Ding, Kaifan Ji, Jiao Li, Chao Liu, Jiangdan Li, Jingxiao Luo, Xin Lyu, Zhanwen Han, Xuefei Chen   +10 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

VLTI/AMBER studies of the atmospheric structure and fundamental parameters of red giant and supergiant stars [Elektronisk resurs]

, 2015
We present recent near-IR interferometric studies of red giant and supergiant stars, which are aimed at obtaining information on the structure of the atmospheric layers and at constraining the fundamental parameters of these objects.
Arroyo-Torres, B., Wood, P. R., Wittkowski, M., Abellan, F. J., Hauschildt, P. H., Scholz, M., Chiavassa, A., Marcaide, J. M., Quirrenbach, A., Marti-Vidal, Ivan,, Freytag, B., Guirado, J. C., Fabregat, J.   +12 more
core  

The Secondary Component of the Extremely Low Mass Ratio Massive Binary HD 165246 Revealed by GHOST

The Astrophysical Journal
In the pursuit of understanding the multiplicity of massive stars, the OWN Survey has undertaken spectroscopic monitoring of hundreds of targets over the past 20 yr.
C. N. Rodriguez, T. Ansin, G. A. Ferrero, O. G. Benvenuto, R. Gamen, N. I. Morrell, J. I. Arias, R. E. Higa, C. Putkuri, C. Johnston, K. Chiboucas, E. Deibert, C. R. Hayes, J.-E. Heo, M. Jeong, V. Kalari, E. Martioli, V. M. Placco, K. A. Venn, S. Xu, R. Diaz, M. Gomez-Jimenez, R. Ruiz-Carmona, C. Simpson, A. W. McConnachie, J. Pazder, G. Burley, T. A. M. Berg, J. G. Robertson, K. Labrie, J. Thomas-Osip   +30 more
doaj   +1 more source

“X-Raying” a Be Star Disk: Fundamental Parameters of the Eclipsing Binary Be Star V658 Car

The Astrophysical Journal
Abstract With its two stellar eclipses and two disk attenuations per binary orbit, V658 Carinae stands out as the first clear eclipsing Be + sdOB system. This rare alignment offers a unique opportunity to probe the structure and dynamics of a Be star disk with unprecedented detail.
de Amorim, TH, Carciofi, AC, Labadie-Bartz, J, Silva, AC, Navarete, F, Rappaport, SA, Querido, P, Rubio, AC, Bjorkman, J, Gagliano, R, Terentev, I   +10 more
openaire   +5 more sources