Results 101 to 110 of about 173,796,379 (301)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

FM stars II: a Fourier view of pulsating binary stars - determining binary orbital parameters photometrically for highly eccentric cases [PDF]

, 2015
Continuous and precise space-based photometry has made it possible to measure the orbital frequency modulation of pulsating stars in binary systems with extremely high precision over long time spans.
Kurtz, Donald W., Murphy, Simon J., Kurtz, Donald Wayne, Murphy, S. J., Shibahashi, Hiromoto, Shibahashi, H.   +5 more
core   +1 more source

Detailed Investigation of a W UMa Contact Binary with an Ultralow Mass Ratio and a Third Body as a Potential Merger Candidate

The Astrophysical Journal
The lower limit of the mass ratio in contact binaries remains uncertain, with observations suggesting systems exist below theoretical predictions. The stability of such very-low-mass-ratio systems is still debated.
Atila Poro, Ehsan Paki, Fahri Alicavus, Raul Michel   +3 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Low-mass Eclipsing Binaries KIC 4908495, KIC 6466939, and KIC 9474485: Isolated Pre-main-sequence Systems?

The Astrophysical Journal
We present a detailed analysis of three Kepler eclipsing binaries, KIC 4908495, KIC 6466939, and KIC 9474485. Our analysis reveals that these systems are composed of components possessing a lower mass than our Sun with slight subsolar metallicities ...
Orkun Özdarcan
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

VLTI/AMBER studies of the atmospheric structure and fundamental parameters of red giant and supergiant stars [Elektronisk resurs]

, 2015
We present recent near-IR interferometric studies of red giant and supergiant stars, which are aimed at obtaining information on the structure of the atmospheric layers and at constraining the fundamental parameters of these objects.
Arroyo-Torres, B., Wood, P. R., Wittkowski, M., Abellan, F. J., Hauschildt, P. H., Scholz, M., Chiavassa, A., Marcaide, J. M., Quirrenbach, A., Marti-Vidal, Ivan,, Freytag, B., Guirado, J. C., Fabregat, J.   +12 more
core  

Photometric and Spectroscopic Studies of Two Early-type Eclipsing Binaries

The Astrophysical Journal
Using high-precision photometric data from the Transiting Exoplanet Survey Satellite, medium-resolution spectroscopic data from the Large Sky Area Multi-Object Fiber Spectroscopy Telescope, and long-term eclipse timings, we provide orbital parameters for
Pengfei Ye, Kai Li, Fei Liu, Xiang Gao, Jing-Yi Wang   +4 more
doaj   +1 more source

“X-Raying” a Be Star Disk: Fundamental Parameters of the Eclipsing Binary Be Star V658 Car

The Astrophysical Journal
Abstract With its two stellar eclipses and two disk attenuations per binary orbit, V658 Carinae stands out as the first clear eclipsing Be + sdOB system. This rare alignment offers a unique opportunity to probe the structure and dynamics of a Be star disk with unprecedented detail.
de Amorim, TH, Carciofi, AC, Labadie-Bartz, J, Silva, AC, Navarete, F, Rappaport, SA, Querido, P, Rubio, AC, Bjorkman, J, Gagliano, R, Terentev, I   +10 more
openaire   +5 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source