Results 71 to 80 of about 201,996 (278)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

An Extremely Hot Pulsating Prewhite Dwarf from OGLE

The Astronomical Journal
We show that the blue 18.3 minutes variable object discovered in the Galactic disk by the OGLE-III survey and named OGLE-GD-WD-0001 is a pulsating prewhite dwarf of PG 1159 spectral type.
Paweł Pietrukowicz, Klaus Werner, Mateusz J. Mróz, Milena Ratajczak   +3 more
doaj   +1 more source

Accurate Fundamental Stellar Parameters

, 2009
We combine results from interferometry, asteroseismology and spectroscopic analyses to determine accurate fundamental parameters (mass, radius and effective temperature) of 10 bright solar-type stars covering the H-R diagram from spectral type F5 to K1 ...
Bruntt, Girardi, Gustafsson, Hans Bruntt, van Leeuwen   +4 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Low-mass Eclipsing Binaries KIC 4908495, KIC 6466939, and KIC 9474485: Isolated Pre-main-sequence Systems?

The Astrophysical Journal
We present a detailed analysis of three Kepler eclipsing binaries, KIC 4908495, KIC 6466939, and KIC 9474485. Our analysis reveals that these systems are composed of components possessing a lower mass than our Sun with slight subsolar metallicities ...
Orkun Özdarcan
doaj   +1 more source

Stellar parameters of Be stars observed with X-shooter

, 2017
Aims. The X-shooter archive of several thousand telluric star spectra was skimmed for Be and Be-shell stars to derive the stellar fundamental parameters and statistical properties, in particular for the less investigated late type Be stars, and the ...
Abo-Elazm, M. S., Beheary, M. M., Faes, D. M., Gadallah, K. A. K, Hamdy, M. A., Hummel, W., Martayan, C., Mehner, A., Mota, B., Mérand, A., Rivinius, Th., Shokry, A., Townsend, R. H. D.   +12 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Photometric and Spectroscopic Studies of Two Early-type Eclipsing Binaries

The Astrophysical Journal
Using high-precision photometric data from the Transiting Exoplanet Survey Satellite, medium-resolution spectroscopic data from the Large Sky Area Multi-Object Fiber Spectroscopy Telescope, and long-term eclipse timings, we provide orbital parameters for
Pengfei Ye, Kai Li, Fei Liu, Xiang Gao, Jing-Yi Wang   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

OO Leo: An Active Contact Binary with Possible Solar-like Differential Rotation

The Astrophysical Journal
With Transiting Exoplanet Survey Satellite (TESS) high-precision photometry and Large Sky Area Multi-object Fiber Spectroscopic Telescope medium-resolution spectra, we present the first light and radial velocity curve analyses for the eclipsing binary OO
Zi-Bin Meng, Pei-Ru Wu, Yun-Xia Yu, Ke Hu, Fu-Yuan Xiang   +4 more
doaj   +1 more source