Results 91 to 100 of about 105,175,213 (210)

The Fundamental k-Form and Global Relations

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2008
In [Proc. Roy. Soc. London Ser. A 453 (1997), no. 1962, 1411-1443] A.S. Fokas introduced a novel method for solving a large class of boundary value problems associated with evolution equations.
Anthony C.L. Ashton
doaj  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Recurrence relations for the W3 $$ {\mathcal{W}}_3 $$ conformal blocks and N=2 $$ \mathcal{N}=2 $$ SYM partition functions

open access: yesJournal of High Energy Physics, 2017
Recursion relations for the sphere 4-point and torus 1-point W3 $$ {\mathcal{W}}_3 $$ conformal blocks, generalizing Alexei Zamolodchikov’s famous relation for the Virasoro conformal blocks are proposed.
Rubik Poghossian
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Lagrange Adjoint System for Linear Fractional Systems with Distributed Delays

open access: yesFractal and Fractional
In the present work we introduce an appropriate definition of the notion of a Lagrange (formal) adjoint system for homogeneous systems with incommensurate-order derivatives in Caputo’s sense and distributed delays. Under natural conditions, the existence
Nedyu Popivanov   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Hyperbolic structures on a toric arrangement complement [PDF]

open access: yes, 2015
This thesis studies the geometric structures on toric arrangement complements. Inspired by the special hypergeometric functions associated with a root system, we consider a family of connections on a total space which is the product of the complement of ...
Shen, Dali   +2 more
core  

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