Results 101 to 110 of about 105,175,213 (210)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Ratio Mathematica, 2013 Let R be a Γ-hyperring and M be an Γ -hypermodule over R. We introduce and tudy fuzzy RΓ -hypermodules. Also, we associate a Γ- hypermodule to every fuzzy Γ-hypermodule and investigate its basic properties.
R. Ameri, R. Sadeghi
doaj
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Hecke algebras, Galois representations, and abelian varieties [PDF]
, 2016 1.The first part of this thesis treats Hecke algebras for linear algebraic groups over either a number field or a non-archimedean local field of characteristic zero. We study to what extent the representation theory of these Hecke algebras determines the
Karemaker, V.Z. +2 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Prediction of Radio-quiet Gamma-Ray Pulsar Distances Using the Fundamental Plane Relation
The Astrophysical JournalThe fundamental plane (FP) relation connects gamma-ray luminosity to intrinsic pulsar properties, offering the potential to estimate distances for radio-quiet (RQ) gamma-ray pulsars, where direct measurements are often unavailable. The Fermi Third Pulsar
Ekrem Oğuzhan Angüner
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Franet National contribution to the Fundamental Rights Report 2025: Portugal
Disclaimer: This document was commissioned under contract as background material for a comparative analysis by the European Union Agency for Fundamental Rights (FRA) for the project ‘FRA Fundamental Rights Report 2025’.
Henriques, Marina +2 more
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